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The present article reviews the electrochemical and electrophysiological performance of platinum<jats:styled-content style=\"fixed-case\">WE<\/jats:styled-content>within a ninety\u2010nine\u2010electrode spiral cuff for selective nerve stimulation and recording of peripheral nerves, with a focus on the vagus nerve (<jats:styled-content style=\"fixed-case\">VN<\/jats:styled-content>). The electrochemical properties of the<jats:styled-content style=\"fixed-case\">WE<\/jats:styled-content>were studied in vitro using the electrochemical impedance spectroscopy (<jats:styled-content style=\"fixed-case\">EIS<\/jats:styled-content>) technique. The equivalent circuit model (<jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>) of the interface between the<jats:styled-content style=\"fixed-case\">WE<\/jats:styled-content>and neural tissue was extracted from the<jats:styled-content style=\"fixed-case\">EIS<\/jats:styled-content>data and simulated in the time domain using a preset current stimulus. Electrophysiological performance of in\u2010space and fiber\u2010type highly selective vagus nerve stimulation (<jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content>) was tested using an isolated segment of a porcine<jats:styled-content style=\"fixed-case\">VN<\/jats:styled-content>and carotid artery as a reference. A quasitrapezoidal current\u2010controlled pulse (stimulus) was applied to the<jats:styled-content style=\"fixed-case\">VN<\/jats:styled-content>or arterial segment using an appointed group of three electrodes (triplet). The triplet and stimulus were configured to predominantly stimulate<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010fibers and minimize the stimulation of A\u2010fibers. The<jats:styled-content style=\"fixed-case\">EIS<\/jats:styled-content>results revealed capacitive charge transfer predominance, which is a highly desirable property. Electrophysiological performance testing indicated the potential existence of certain parameters and waveforms of the stimulus for which the contribution of the A\u2010fibers to the<jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>decreased slightly and that of the<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010fibers increased slightly. Findings show that the design of the stimulating electrodes, based on the<jats:styled-content style=\"fixed-case\">EIS<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>results, could act as a useful tool for nerve cuff development.<\/jats:p>","DOI":"10.1111\/aor.12625","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T08:14:19Z","timestamp":1444983259000},"page":"886-896","source":"Crossref","is-referenced-by-count":3,"title":["Electrochemical and Electrophysiological Performance of Platinum Electrodes Within the Ninety\u2010Nine\u2010Electrode Stimulating Nerve Cuff"],"prefix":"10.1111","volume":"39","author":[{"given":"Polona","family":"Pe\u010dlin","sequence":"first","affiliation":[{"name":"Center for Implantable Technology and Sensors ITIS d. o. o. 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