{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T23:43:00Z","timestamp":1786232580553,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T00:00:00Z","timestamp":1448582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T00:00:00Z","timestamp":1448582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Abstract<\/jats:title>\n \n The objective of this study is to evaluate the preoperative coagulation pattern and its association to postoperative blood products transfusion in children with congenital heart disease (\n CH<\/jats:styled-content>\n D), focusing on cyanotic patients (oxygen saturation,\n SATO<\/jats:styled-content>\n 2<\/jats:sub>\n \u2009<\u200985%). From\n J<\/jats:styled-content>\n anuary to\n A<\/jats:styled-content>\n ugust 2014, preoperative standard coagulation tests and rotational thromboelastometry assays were performed on 81 pediatric patients (<16 years old) who underwent surgery for\n CHD<\/jats:styled-content>\n with the aid of cardiopulmonary bypass. Sixty patients (74%) were acyanotic and 21 (26%) cyanotic. Mean age at time of surgery was 7.9 months (interquartile range 2.9\u201343.6 months). Cyanotic patients had a significantly higher hematocrit (\n P<\/jats:italic>\n \u2009<\u20090.001), a reduced prothrombin activity (\n PT<\/jats:styled-content>\n ) (\n P<\/jats:italic>\n \u2009=\u20090.01) level, and a lower platelet count (\n P<\/jats:italic>\n \u2009=\u20090.02) than acyanotic patients. An inverse linear association was found between patient's\n SATO<\/jats:styled-content>\n 2 and clot formation time (\n CFT<\/jats:styled-content>\n ) (\n INTEM<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.001, and\n EXTEM<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009<\u20090.0001). A direct linear association was found between patient's\n SATO<\/jats:styled-content>\n 2 and maximum clot firmness (\n MCF<\/jats:styled-content>\n ) (\n INTEM<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.04, and\n EXTEM<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.05). Preoperative cyanosis was also associated with a lower median\n MCF<\/jats:styled-content>\n in\n FIBTEM<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009=\u20090.02). Cyanotic patients required more frequent postoperative transfusions of fibrinogen (7\/21 patients, 33% vs. 4\/60 patients, 6.7%,\n P<\/jats:italic>\n \u2009=\u20090.01) and fresh frozen plasma (14\/21, 67% vs. 25\/60, 42%,\n P<\/jats:italic>\n \u2009=\u20090.08). Patients with a lower presurgery\n PT<\/jats:styled-content>\n and platelet count subsequently required more fibrinogen transfusion\n P<\/jats:italic>\n \u2009=\u20090.02 and\n P<\/jats:italic>\n \u2009=\u20090.003, respectively); the same goes for patients with a longer\n CFT<\/jats:styled-content>\n (\n INTEM<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.01 and\n EXTEM<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.03) and a reduced\n MCF<\/jats:styled-content>\n (\n INTEM<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.02 and\n FIBTEM<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u2009=\u20090.01) as well. Cyanotic patients showed significant preoperative coagulation anomalies and required a higher postoperative fibrinogen supplementation. The preoperative\n MCF FIBTEM<\/jats:styled-content>\n has become an important factor in our postoperative thromboelastometry\u2010guided transfusion protocols.\n <\/jats:p>","DOI":"10.1111\/aor.12629","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T02:45:06Z","timestamp":1448592306000},"page":"698-705","source":"Crossref","is-referenced-by-count":21,"title":["The Coagulative Profile of Cyanotic Children Undergoing Cardiac Surgery: The Role of Whole Blood Preoperative Thromboelastometry on Postoperative Transfusion Requirement"],"prefix":"10.1111","volume":"40","author":[{"given":"Vladimiro L.","family":"Vida","sequence":"first","affiliation":[{"name":"Pediatric and Congenital Cardiac Surgery Unit Department of Cardiac, Thoracic, and Vascular Sciences University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Spiezia","sequence":"additional","affiliation":[{"name":"Vascular Medicine Unit, Department of Medicine (DIMED) University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Bortolussi","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiac Surgery Unit Department of Cardiac, Thoracic, and Vascular Sciences University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta E.","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiac Surgery Unit Department of Cardiac, Thoracic, and Vascular Sciences University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Campello","sequence":"additional","affiliation":[{"name":"Vascular Medicine Unit, Department of Medicine (DIMED) University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrio","family":"Pittarello","sequence":"additional","affiliation":[{"name":"Cardiac Anesthesia Unit, Department of Medicine (DIMED) University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Gregori","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health Unit Department of Cardiac, Thoracic, and Vascular Sciences University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Stellin","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiac Surgery Unit Department of Cardiac, Thoracic, and Vascular Sciences University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Simioni","sequence":"additional","affiliation":[{"name":"Vascular Medicine Unit, Department of Medicine (DIMED) University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcan.2002.128436"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu412"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2006.33.10.617"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.06.019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2005.00681.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2013.08.004"},{"key":"e_1_2_8_8_1","first-page":"227","volume-title":"Harrison's Principles of Medicine","author":"Braunwald E","year":"1991"},{"key":"e_1_2_8_9_1","unstructured":"R Core Team.R: A language and environment for statistical computing. 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