{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:05:23Z","timestamp":1777356323423,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T00:00:00Z","timestamp":1448496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Extracorporeal membrane oxygenation (ECMO<\/jats:styled-content>) has traditionally been and, for the most part, still is being performed using roller pumps. Use of first\u2010generation centrifugal pumps has yielded controversial outcomes, perhaps due to mechanical properties of the same and the ensuing risk of hemolysis and renal morbidity. Latest\u2010generation centrifugal pumps, using magnetic levitation (ML), exhibit mechanical properties which may have overcome limitations of first\u2010generation devices. This retrospective study aimed to assess the safety and efficacy of veno\u2010arterial (V<\/jats:styled-content>\u2010A) ECMO<\/jats:styled-content> for cardiac indications in neonates, infants, and children, using standard (SP<\/jats:styled-content>) and latest\u2010generation ML<\/jats:styled-content> centrifugal pumps. Between 2002 and 2014, 33 consecutive neonates, infants, and young children were supported using V<\/jats:styled-content>\u2010A ECMO<\/jats:styled-content> for cardiac indications. There were 21 males and 12 females, with median age of 29 days (4 days\u20135 years) and a median body weight of 3.2\u2009kg (1.9\u201318\u2009kg). Indication for V<\/jats:styled-content>\u2010A ECMO<\/jats:styled-content> were acute circulatory collapse in ICU<\/jats:styled-content> or ward after cardiac repair in 16 (49%) patients, failure to wean after repair of complex congenital heart disease in 9 (27%), fulminant myocarditis in 4 (12%), preoperative sepsis in 2 (6%), and refractory tachy\u2010arrhythmias in 2 (6%). Central cannulation was used in 27 (81%) patients and peripheral in 6. Seven (21%) patients were supported with SP<\/jats:styled-content> and 26 (79%) with ML<\/jats:styled-content> centrifugal pumps. Median duration of support was 82\u2009h (range 24\u2013672\u2009h), with 26 (79%) patients weaned from support. Three patients required a second ECMO<\/jats:styled-content> run but died on support. Seventeen (51%) patients required peritoneal dialysis for acute renal failure. Overall survival to discharge was 39% (13\/33 patients). All patients with fulminant myocarditis and with refractory arrhythmias were weaned, and five (83%) survived, whereas no patient supported for sepsis survived. Risk factors for hospital mortality included lower (<2.5\u2009kg) body weight (P<\/jats:italic>\u2009=\u20090.02) and rescue ECMO<\/jats:styled-content> after cardiac repair (P<\/jats:italic>\u2009=\u20090.03). During a median follow\u2010up of 34 months (range 4\u201362 months), there were three (23%) late deaths and two late survivors with neurological sequelae. Weaning rate (5\/7 vs. 21\/26, P<\/jats:italic>\u2009=\u2009NS<\/jats:styled-content>) and prevalence of renal failure requiring dialysis (4\/7 vs. 13\/26, P<\/jats:italic>\u2009=\u2009NS<\/jats:styled-content>) were comparable between SP<\/jats:styled-content> and ML ECMO<\/jats:styled-content> groups. Patients supported with ML<\/jats:styled-content> had a trend toward higher hospital survival (1\/7 vs. 12\/26, P<\/jats:italic>\u2009=\u20090.07) and significantly higher late survival (0\/7 vs. 10\/26, P<\/jats:italic>\u2009=\u20090.05). The present experience shows that V<\/jats:styled-content>\u2010A ECMO<\/jats:styled-content> for cardiac indications using centrifugal pumps in infants and children yields outcomes absolutely comparable to international registry (ELSO<\/jats:styled-content>) data using mostly roller pumps. Although changes in practice may have contributed to these results, use of ML centrifugal pumps appears to further improve end\u2010organ recovery and hospital and late survival.<\/jats:p>","DOI":"10.1111\/aor.12647","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T12:12:21Z","timestamp":1448539941000},"page":"27-33","source":"Crossref","is-referenced-by-count":20,"title":["Improved Outcome of Cardiac Extracorporeal Membrane Oxygenation in Infants and Children Using Magnetic Levitation Centrifugal Pumps"],"prefix":"10.1111","volume":"40","author":[{"given":"Giovanni Battista","family":"Luciani","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stiljan","family":"Hoxha","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Torre","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Rungatscher","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziano","family":"Menon","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Barozzi","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Faggian","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197203232861204"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0022-5223(19)39687-4","article-title":"Prolonged extracorporeal cardiopulmonary support in man","volume":"68","author":"Bartlett RH","year":"1974","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04310-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1051\/ject\/201143236","article-title":"Neonatal extracorporeal membrane oxygenation devices, techniques and team roles: 2011 survey results of the United States\u2019 Extracorporeal Life Support Organization centers","volume":"43","author":"Lawson S","year":"2011","journal-title":"J Extra Corpor Technol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.06.061"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000128"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31822e2475"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31823c98ef"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs524"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)01089-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2010.01134.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12115"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659113509000"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12290"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12466"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt427"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31824174c8"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3182a553f3"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12647","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:06:51Z","timestamp":1695712011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,26]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/aor.12647"],"URL":"https:\/\/doi.org\/10.1111\/aor.12647","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,26]]}}}