{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:05:41Z","timestamp":1696521941338},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Durability of pulmonary conduits (PCs<\/jats:styled-content>) used for reconstruction of the right ventricular outflow tract (RVOT<\/jats:styled-content>) may be affected by a variety of factors. Among these, the technique used for PC<\/jats:styled-content> implantation, whether in orthotopic or heterotopic position, strictly dependent upon the underlying anatomy, has been suggested to influence long\u2010term outcome after RVOT<\/jats:styled-content> repair. To determine the outcome of heterotopic implantation in infants and children treated at our institution, late results of heterotopic PC<\/jats:styled-content> in non\u2010Ross patients were analyzed and compared with data of orthotopic PC<\/jats:styled-content> in age\u2010matched pediatric R<\/jats:styled-content>oss patients operated during the same time period. Between N<\/jats:styled-content>ovember 1991 and J<\/jats:styled-content>anuary 2015, 58 infants and children, 32 male and 26 female, with a median age of 9.4 years (range 1 day\u201318 years) underwent implantation of heterotopic PC<\/jats:styled-content> (31 homografts [HG<\/jats:styled-content>] and 27 xenografts [XG<\/jats:styled-content>]) for reconstruction of RVOT<\/jats:styled-content>. Median age in the XG<\/jats:styled-content> group was significantly lower than in the HG<\/jats:styled-content> group (0.9 vs. 13.4 years, P<\/jats:italic><\/jats:styled-content>\u2009=\u20090.01), while male\/female ratio was similar. Fifty (86%) patients had undergone one or more prior cardiac operations, while 32 (55%) required associated procedures during PC<\/jats:styled-content> implantation. Comparison with data in 305 children and with a median age of 9.4 years, receiving orthotopic PC<\/jats:styled-content> between 1990 and 2012 (I<\/jats:styled-content>talian P<\/jats:styled-content>ediatric R<\/jats:styled-content>oss R<\/jats:styled-content>egistry), was undertaken. Descriptive, univariate, and K<\/jats:styled-content>aplan\u2013M<\/jats:styled-content>eier analysis defined outcome. There were three (5.2%) early and five (9.0%) late deaths, during a median follow\u2010up of 7.6 years (range 2 months\u201323 years). Patients having XG<\/jats:styled-content> had trend toward higher hospital mortality (2\/27 vs. 1\/31, P<\/jats:italic>\u2009=\u20090.2), but similar late mortality (2\/24 vs. 3\/30, P<\/jats:italic>\u2009=\u20090.3). Overall survival was 88 and 62%, while freedom from PC<\/jats:styled-content> replacement was 49 and 21%, at 10 and 20 years, respectively. The latter proved significantly worse than freedom from orthotopic PC<\/jats:styled-content> replacement, which was 94\u2009\u00b1\u20092 and 70\u2009\u00b1\u20099% at 10 and 20 years (P<\/jats:italic>\u2009=\u20090.02). When stratified for type of heterotopic PC<\/jats:styled-content>, late survival proved comparable (81 and 81% for XG<\/jats:styled-content> vs. 92 and 60% for HG<\/jats:styled-content>, at 10 and 20 years, respectively, P<\/jats:italic><\/jats:styled-content>\u2009=\u20090.7). However, freedom from PC<\/jats:styled-content> replacement was significantly higher in patients with heterotopic HG<\/jats:styled-content> (21 and 5% for XG<\/jats:styled-content> vs. 63 and 48% for HG<\/jats:styled-content>, at 10 and 20 years, respectively, P<\/jats:italic>\u2009=\u20090.001). RVOT<\/jats:styled-content> repair using either XG<\/jats:styled-content> or HG<\/jats:styled-content> in heterotopic position is a safe procedure associated with low hospital mortality and satisfactory late survival. Freedom from reoperation is significantly lower than that observed in age\u2010matched children having orthotopic HG<\/jats:styled-content>. Freedom from reoperation in heterotopic XG<\/jats:styled-content> is poorer than in HG<\/jats:styled-content>, although different baseline demography may have influenced this finding.<\/jats:p>","DOI":"10.1111\/aor.12648","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T10:41:02Z","timestamp":1448966462000},"page":"50-55","source":"Crossref","is-referenced-by-count":2,"title":["Twenty\u2010Year Outcome After Right Ventricular Outflow Tract Repair Using Heterotopic Pulmonary Conduits in Infants and Children"],"prefix":"10.1111","volume":"40","author":[{"given":"Stiljan","family":"Hoxha","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Torre","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Rungatscher","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Sandrini","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Rossetti","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Barozzi","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Faggian","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Battista","family":"Luciani","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Department of Surgery University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)90600-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.03.061"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.03.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.suppl_3.III-130"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.02.053"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.12.054"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-305873"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.02.063"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezr221"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.12.052"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.05.074"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.02.073"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135111415711"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(00)00628-X"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12648","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:06:53Z","timestamp":1695712013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/aor.12648"],"URL":"https:\/\/doi.org\/10.1111\/aor.12648","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}