{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:03:00Z","timestamp":1792065780406,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T00:00:00Z","timestamp":1449532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Mixing of autologous blood with priming volume has relatively significant effects on blood composition, especially in low\u2010bodyweight neonates. In an effort to reduce these effects, mini\u2010volume priming (MP<\/jats:styled-content>) has been applied in cardiopulmonary bypass (CPB<\/jats:styled-content>). The present study was designed to examine the effect of MP<\/jats:styled-content> on clinical outcomes of low\u2010bodyweight neonates undergoing open heart surgery.We retrospectively reviewed medical records of low\u2010bodyweight (2.5\u2009kg or less) neonates who underwent open heart surgery in our center from J<\/jats:styled-content>anuary 2000 to D<\/jats:styled-content>ecember 2014. A total of 64 patients were included. MP<\/jats:styled-content> was introduced in 2007, and became a routine protocol in 2009. Preoperative and intraoperative characteristics included age, bodyweight, RACHS<\/jats:styled-content>\u20101, priming volume, CPB<\/jats:styled-content> time, and aortic cross\u2010clamp time, transfusion, and hematocrit during CPB<\/jats:styled-content>. Clinical outcomes included 30\u2010day mortality, postoperative extracorporeal membrane oxygenation (ECMO<\/jats:styled-content>) support, open sternum status, prolonged mechanical ventilation care (>7 days), and acute renal failure. MP<\/jats:styled-content> was utilized in 39 patients and conventional priming (CP<\/jats:styled-content>) was used in 25 patients. The priming volume decreased to 126.0\u2009mL in the MP<\/jats:styled-content> group compared with 321.6\u2009mL in the CP<\/jats:styled-content> group. Transfusion volume during CPB<\/jats:styled-content> was 87.3\u2009mL in the MP<\/jats:styled-content> group versus 226.8\u2009mL in the CP<\/jats:styled-content> group, and the difference was statistically significant (P<\/jats:italic>\u2009<\u20090.001). Hematocrit at the end of the CPB<\/jats:styled-content> and maximal decrease of hematocrit during CPB<\/jats:styled-content> were not significantly different between the two groups. The 30\u2010day mortality rate was 12.8% in the MP<\/jats:styled-content> group versus 20.0% in the CP<\/jats:styled-content> group. Postoperative ECMO<\/jats:styled-content> support was performed in 5.1% of patients in the MP<\/jats:styled-content> group versus 17.4% of patients in the CP<\/jats:styled-content> group. Open sternum status was required in 20.8% of patients in the MP<\/jats:styled-content> group versus 10.3% of patients in the CP<\/jats:styled-content> group, and prolonged ventilator care was required in 54.2% of patients in the MP<\/jats:styled-content> group versus 38.5% of patients in the CP<\/jats:styled-content> group. However, no statistical significance was measured in any of the clinical outcome measures. Larger priming volume and higher RACHS<\/jats:styled-content>\u20101 were significant risk factors of postoperative ECMO<\/jats:styled-content> support in univariate and multivariate analysis. The results of the present study suggest that MP<\/jats:styled-content> may be beneficial in avoiding transfusion without having a significant effect on the hematocrit. Clinical outcomes did not differ between the two groups. However, larger priming volume was a significant risk factor for postoperative ECMO<\/jats:styled-content> support with RACHS<\/jats:styled-content>\u20101 category.<\/jats:p>","DOI":"10.1111\/aor.12657","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T05:40:38Z","timestamp":1449639638000},"page":"73-79","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Mini\u2010Volume Priming During Cardiopulmonary Bypass on Clinical Outcomes in Low\u2010Bodyweight Neonates: Less Transfusion and Postoperative Extracorporeal Membrane Oxygenation Support"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8313-8053","authenticated-orcid":false,"given":"Sang Yoon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery College of Medicine Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungkyu","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery College of Medicine Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunseok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Cardiovascular Center Sejong General Hospital Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong\u2010Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery College of Medicine Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.05.049"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-011-9910-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.01.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12241"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.119064"},{"key":"e_1_2_6_7_1","first-page":"418","article-title":"Minimized priming volume for open heart surgery in neonates and infants","volume":"42","author":"Kim W\u2010H","year":"2009","journal-title":"Korean J Thorac Cardiovasc Surg"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.142174"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2544-x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000153"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.05.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31819742f0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.02.020"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.01.068"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659114535649"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00935.x"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12657","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:06:34Z","timestamp":1695711994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,8]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/aor.12657"],"URL":"https:\/\/doi.org\/10.1111\/aor.12657","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,8]]}}}