{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:33Z","timestamp":1740126033581,"version":"3.37.3"},"reference-count":8,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005969","name":"University of Bologna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Abstract<\/jats:title>Parathyroid hormone (PTH<\/jats:styled-content>) determination is essential for the diagnosis of renal osteodystrophy, but differences between the laboratory assays can lead to different therapies. This study compared the new T<\/jats:styled-content>osoh ST AIA<\/jats:styled-content>\u2010Pack Intact PTH<\/jats:styled-content> assay (Tosoh Bioscience, San Francisco, CA, USA) with the E<\/jats:styled-content>lecsys I<\/jats:styled-content>ntact PTH R<\/jats:styled-content>oche assay (Roche Diagnostics GmbH, Mannheim, Germany), currently considered the gold standard. Nineteen chronic stable hemodialysis patients were enrolled to check PTH<\/jats:styled-content> levels with the two assays. Median age was 71 years (range 26\u201384), M<\/jats:styled-content>\/F<\/jats:styled-content>\u2009=\u200910\/9. Blood samples were taken before the start of the same midweek dialysis session. Two blood vacuettes were collected and immediately transported to the central laboratory. The median PTH<\/jats:styled-content> value was 268 (range 35\u2013901\u2009pg\/dL) with the AIA<\/jats:styled-content>\u2010P<\/jats:styled-content>ack versus 184 (range 39\u2013552\u2009pg\/dL) with E<\/jats:styled-content>lecsys. The W<\/jats:styled-content>ilcoxon test showed a significant difference between the two methods (P<\/jats:italic>\u2009<\u20090.0001). AIA<\/jats:styled-content>\u2010P<\/jats:styled-content>ack showed a delta value of +38% in comparison with E<\/jats:styled-content>lecsys and a median bias of 27.4%. For PTH<\/jats:styled-content> values <150\u2009pg\/dL, nine patients were detected with AIA<\/jats:styled-content>\u2010P<\/jats:styled-content>ack (47.4%) versus nine patients detected with E<\/jats:styled-content>lecsys (47.4%). For PTH<\/jats:styled-content> values between 150 and 300\u2009pg\/dL, six patients were detected with AIA<\/jats:styled-content>\u2010P<\/jats:styled-content>ack (31.6%) versus four patients with E<\/jats:styled-content>lecsys (21.0%). For PTH<\/jats:styled-content> values >300\u2009pg\/dL four patients were detected with AIA<\/jats:styled-content>\u2010P<\/jats:styled-content>ack (21.0%) versus six patients with E<\/jats:styled-content>lecsys (31.6%). The two assays showed no differences for each of the three PTH<\/jats:styled-content> ranges considered. The two PTH<\/jats:styled-content> assays tested are different and the attending physician should be aware of the differences when patients change their dialysis facility.<\/jats:p>","DOI":"10.1111\/aor.12661","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T10:13:45Z","timestamp":1450260825000},"page":"1013-1016","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Two Parathyroid Hormone Assays in Hemodialysis Patients"],"prefix":"10.1111","volume":"40","author":[{"given":"Gabriele","family":"Donati","sequence":"first","affiliation":[{"name":"Nephrology Dialysis and Renal Transplantation Unit S. Orsola University Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Cianciolo","sequence":"additional","affiliation":[{"name":"Nephrology Dialysis and Renal Transplantation Unit S. Orsola University Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Capelli","sequence":"additional","affiliation":[{"name":"Nephrology Dialysis and Renal Transplantation Unit S. Orsola University Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Baraldi","sequence":"additional","affiliation":[{"name":"Nephrology Dialysis and Renal Transplantation Unit S. Orsola University Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Gambaretto","sequence":"additional","affiliation":[{"name":"Nephrology Dialysis and Renal Transplantation Unit S. Orsola University Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Demelas","sequence":"additional","affiliation":[{"name":"Nephrology Dialysis and Renal Transplantation Unit S. Orsola University Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Public Heath University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"La Manna","sequence":"additional","affiliation":[{"name":"Nephrology Dialysis and Renal Transplantation Unit S. Orsola University Hospital Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.374"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001606"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001658"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001599"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/clinchem\/44.4.805","article-title":"A non\u2010(1\u201384) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples","volume":"44","author":"Lepage R","year":"1998","journal-title":"Clin Chem"},{"issue":"3","key":"e_1_2_8_7_1","first-page":"S1","article-title":"K\/DOQI Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease","volume":"42","author":"National Kidney Foundation","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.071589"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2009.068"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12661","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T06:25:05Z","timestamp":1695709505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,16]]},"references-count":8,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/aor.12661"],"URL":"https:\/\/doi.org\/10.1111\/aor.12661","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"type":"print","value":"0160-564X"},{"type":"electronic","value":"1525-1594"}],"subject":[],"published":{"date-parts":[[2015,12,16]]}}}