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The <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> frequency used in the clinic today is in the range of 10\u201330\u2009Hz. The evidence for choosing the stimulation frequency is limited, and little knowledge is available on the effect of other <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> frequencies. Deep brain, trigeminal nerve, or spinal cord stimulation studies have suggested the use of stimulation frequencies above 80\u2009Hz for seizure control. Therefore, our objective for the present study was to investigate if <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> using frequencies higher than those currently used in the clinic could be more effective in attenuating seizures. Spike\u2010and\u2010wave (<jats:styled-content style=\"fixed-case\">SW<\/jats:styled-content>) discharges were induced in 11 rats, which then were subjected to <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> sessions applied at the frequencies of 10, 30, 80, 130, and 180\u2009Hz combined with control intervals without stimulation. The anticonvulsive effect of <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> was evaluated by comparing the normalized mean power (nMP) and frequency (nMSF) of the <jats:styled-content style=\"fixed-case\">SW<\/jats:styled-content> discharges derived from intracortical recordings collected during the stimulation and control intervals. Compared with the control intervals, all the tested <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> frequencies significantly reduced the nMP (in the range of 9\u201321%). However, we found that 130 and 180\u2009Hz <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> induced a 50% larger attenuation of seizures than that achieved by 30\u2009Hz <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content>. In addition, we found that 80, 130, and 180\u2009Hz <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> induced a significant reduction of the nMSF, that is by 5, 7, and 8%, respectively. These results suggest that a <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> stimulation frequency in the range of 130\u2013180\u2009Hz may be more effective in inhibiting seizures than the 30\u2009Hz <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> applied in the clinic today.<\/jats:p>","DOI":"10.1111\/aor.12669","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T21:18:33Z","timestamp":1451423913000},"source":"Crossref","is-referenced-by-count":15,"title":["Optimal Vagus Nerve Stimulation Frequency for Suppression of Spike\u2010and\u2010Wave Seizures in Rats"],"prefix":"10.1111","volume":"40","author":[{"given":"Jianhang","family":"Jiao","sequence":"first","affiliation":[{"name":"Center for Sensory\u2010Motor Interaction Department of Health Science and Technology Faculty of Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian R.","family":"Harreby","sequence":"additional","affiliation":[{"name":"Center for Sensory\u2010Motor Interaction Department of Health Science and Technology Faculty of Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Sevcencu","sequence":"additional","affiliation":[{"name":"Center for Sensory\u2010Motor Interaction Department of Health Science and Technology Faculty of Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winnie","family":"Jensen","sequence":"additional","affiliation":[{"name":"Center for Sensory\u2010Motor Interaction Department of Health Science and Technology Faculty of Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12888"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2007.01.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00220-X"},{"key":"e_1_2_7_5_1","first-page":"518","article-title":"Time course of seizure control to breaf repetitive stimuli","volume":"26","author":"Zabara J","year":"1985","journal-title":"Epilepsia"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1990.tb05852.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1990.tb05844.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1992.tb01751.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.91610"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03646.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"8160","DOI":"10.1523\/JNEUROSCI.20-21-08160.2000","article-title":"Reduction of pentylenetetrazole\u2010induced seizure activity in awake rats by seizure\u2010triggered trigeminal nerve stimulation","volume":"20","author":"Fanselow EE","year":"2000","journal-title":"J Neurosci"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323343"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(97)00034-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2013.03.009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12362"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(97)00091-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24399"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.01.004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.59"},{"volume-title":"The Rat Brain in Stereotaxic Coordinates","year":"2007","author":"Paxinos G","key":"e_1_2_7_20_1"},{"key":"e_1_2_7_21_1","unstructured":"Cyberonics.VNS Therapy System Physician's Manual.2014. 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