{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:20:55Z","timestamp":1790878855308,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T00:00:00Z","timestamp":1461542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic kidney disease\u2010mineral and bone disorder (CKD\u2010BMD) is a condition known to be associated with cardiovascular disease and mortality in hemodialysis (HD) patients. The relation between calcium (Ca), phosphorus (P), and intact parathyroid hormone (iPTH) variability in HD patients and cardiac mortality is unknown. The purpose of this study was to assess the relation between variability in these parameters and cardiac mortality. Baseline demographic and biochemical parameters of 218 HD patients together with Ca values corrected with albumin and P values measured on a monthly basis and iPTH levels measured at 3\u2010monthly intervals were recorded over 2 years. Standard deviation (SD) and smoothness index (SI) for each parameter were calculated to assess Ca, P, and iPTH variability. The relations between all parameters and cardiac mortality were then analyzed. Cardiac mortality was observed in 38 patients in the 2\u2010year study period. Nonsurviving patients' ages, systolic and diastolic blood pressure (DBP), high sensitivity C\u2010reactive protein (HsCRP) levels, mean iPTH, and SD iPTH were significantly higher than those of surviving patients, while albumin levels, SI iPTH and SI Ca were significantly lower. Age, low albumin, high DBP, SI iPTH, and SI Ca were identified as independent predictors of cardiac mortality at multivariate analysis. Our study shows that Ca and iPTH variability affect cardiac mortality independently of mean and baseline values. When supported by further studies, the relation between Ca and iPTH variability and cardiac mortality in HD patients can lead to a new perspective in terms of prognosis and treatment planning.<\/jats:p>","DOI":"10.1111\/aor.12690","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T13:11:52Z","timestamp":1461589912000},"page":"1078-1085","source":"Crossref","is-referenced-by-count":8,"title":["The Relation Between Variability of Intact Parathyroid Hormone, Calcium, and Cardiac Mortality in Hemodialysis Patients"],"prefix":"10.1111","volume":"40","author":[{"given":"Sukru","family":"Ulusoy","sequence":"first","affiliation":[{"name":"Department of Nephrology, School of Medicine Karadeniz Technical University Trabzon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsum","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hatay Antakya State Hospital Hatay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beyhan","family":"Guvercin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Karadeniz Technical University Trabzon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Trabzon RNS Hemodialysis Center Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01170905"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1488"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.27380"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04331206"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.020"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.254"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.189"},{"key":"e_1_2_6_9_1","first-page":"1","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease\u2010Mineral and Bone Disorder (CKD\u2010MBD)","volume":"113","author":"Kidney Disease: Improving Global 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