{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:12:19Z","timestamp":1696522339547},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Excessive left ventricular (LV) volume unloading can affect right ventricular (RV) function by causing a leftward shift of the interventricular septum in patients with mitral regurgitation (MR) receiving left ventricular assist device (LVAD) support. Optimal settings for the LVAD should be chosen to appropriately control the MR without causing RV dysfunction. In this study, we assessed the utility of our electrocardiogram\u2010synchronized rotational speed (RS) modulation system along with a continuous\u2010flow LVAD in a goat model of MR. We implanted EVAHEART devices after left thoracotomy in six adult goats weighing 66.4\u2009\u00b1\u200910.7 kg. Severe MR was induced through inflation of a temporary inferior vena cava filter placed within the mitral valve. We evaluated total flow (TF; the sum of aortic flow and pump flow [PF]), RV fractional area change (RVFAC) calculated by echocardiography, left atrial pressure (LAP), LV end\u2010diastolic pressure (LVEDP), LV end\u2010diastolic volume (LVEDV), and LV stroke work (LVSW) with a bypass rate (PF divided by TF) of 100% under four conditions: circuit\u2010clamp, continuous mode, co\u2010pulse mode (increased RS during systole), and counter\u2010pulse mode (increased RS during diastole). TF tended to be higher in the counter\u2010pulse mode. Moreover, RVFAC was significantly higher in the counter\u2010pulse mode than in the co\u2010pulse mode, whereas LAP was significantly lower in all driving modes than in the circuit\u2010clamp condition. Furthermore, LVEDP, LVEDV, and LVSW were significantly lower in the counter\u2010pulse mode than in the circuit\u2010clamp condition. The counter\u2010pulse mode of our RS modulation system used with a continuous\u2010flow LVAD may offer favorable control of MR while minimizing RV dysfunction.<\/jats:p>","DOI":"10.1111\/aor.12702","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T13:53:16Z","timestamp":1463838796000},"page":"1039-1045","source":"Crossref","is-referenced-by-count":8,"title":["What Is the Optimal Setting for a Continuous\u2010Flow Left Ventricular Assist Device in Severe Mitral Regurgitation?"],"prefix":"10.1111","volume":"40","author":[{"given":"Noritsugu","family":"Naito","sequence":"first","affiliation":[{"name":"Department of Artificial Organs National Cerebral and Cardiovascular Center, Research Institute Osaka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Tokyo Metropolitan Geriatric Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Takewa","sequence":"additional","affiliation":[{"name":"Department of Artificial Organs National Cerebral and Cardiovascular Center, Research Institute Osaka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Artificial Organs National Cerebral and Cardiovascular Center, Research Institute Osaka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuma","family":"Date","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihide","family":"Umeki","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"Department of Artificial Organs National Cerebral and Cardiovascular Center, Research Institute 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