{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:58:36Z","timestamp":1771012716553,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T00:00:00Z","timestamp":1479772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 81370432"],"award-info":[{"award-number":["NSFC 81370432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The objective of this study is to compare the myocardium protective effect of Bretschneider's histidine\u2010tryptophan\u2010ketoglutarate (HTK) solution versus Modified St. Thomas' (STH) solution in pediatric cardiac surgery of Tetralogy of Fallot (TOF). Seventy\u2010seven pediatric patients of TOF who received the total surgical repair were reviewed, from January 2014 to October 2015. A horizontal comparison between HTK solution and modified STH solution has been made since the HTK solutions were started to be used in our hospital. The patients were divided into the HTK group (<jats:italic>n<\/jats:italic>\u2009=\u200935) and the STH group (<jats:italic>n<\/jats:italic>\u2009=\u200933). The perioperative values of the groups were assessed in this study. The primary endpoints including spontaneous cardiac re\u2010beating time, intensive care unit (ICU) stay, overall stay, mechanical ventilation postoperation, postoperation stay, overall stay, and perioperative echocardiographic results were analyzed in this study. We found that spontaneous cardiac re\u2010beating time of the HTK group was significantly shorter than that of the STH group (0.26 min\u2009\u00b1\u20090.56 vs. 1.33\u2009\u00b1\u20091.02, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). There were no significant differences between the two groups in ICU stay (<jats:italic>P<\/jats:italic>\u2009=\u20090.29), postoperative mechanical ventilation time (<jats:italic>P<\/jats:italic>\u2009=\u20090.84), overall stay (0.73); and the mortalities of the two groups were similar (2.9 vs. 3.0%). Aimed at pediatric cardiac surgery of TOF, this study suggests that with similar aorta cross\u2010clamping time, modified STH solution is as safe as HTK solution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.12771","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T03:58:45Z","timestamp":1479873525000},"page":"470-475","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Assessment of Histidine\u2010Tryptophan\u2010Ketoglutarate Solution and Modified St. Thomas' Solution in Pediatric Cardiac Surgery of Tetralogy of Fallot"],"prefix":"10.1111","volume":"41","author":[{"given":"Zhao\u2010Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery People's Hospital of Dongyang, Dongyang"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"An","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Children's Hospital of Chongqing Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Cheng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Children's Hospital of Chongqing Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010Jiang","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Children's Hospital of Chongqing Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin\u2010Bei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Children's Hospital of Chongqing Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Zhen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Cardiovascular Perfusion Children's Hospital of Chongqing Medical University Chongqing R.P. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Qun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Cardiovascular Perfusion Children's Hospital of Chongqing Medical University Chongqing R.P. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,22]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"171","article-title":"Application of a mechanical heart and lung apparatus to cardiac surgery","volume":"37","author":"Gibbon JH","year":"1954","journal-title":"Minn Med"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs319"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195509000-00010"},{"key":"e_1_2_9_6_1","first-page":"272","article-title":"Tetralogy of Fallot. 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