{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:31:40Z","timestamp":1789723900851,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early graft failure (EGF) is a major risk factor for death after heart transplantation (Htx). We investigated the predictive risk factors for moderate\u2010to\u2010severe EGF requiring an intra\u2010aortic balloon pump (IABP) or extracorporeal membrane oxygenation (ECMO) circulatory support as treatment after Htx. Between January 2000 and December 2014, 412 consecutive adult patients underwent isolated Htx at our institution. Moderate and severe EGF were defined as the need for IABP and ECMO support, respectively, within 24 h after Htx. All available recipient and donor variables were analyzed to assess the risk of EGF occurrence. Overall, moderate\u2010to\u2010severe EGF occurred in 46 (11.1%) patients. Twenty\u2010nine (63.04%) patients required peripheral or central ECMO support in the treatment of severe EGF and 17 (36.9%) patients required IABP support for the treatment of moderate EGF. The predictive risk factors for moderate\u2010to\u2010severe EGF in recipients, as assessed by logistic regression analysis, were a preoperative transpulmonary gradient\u2009&gt;\u200912 mm\u00a0Hg (odds ratio [OR] 5.2; <jats:italic>P<\/jats:italic>\u2009=\u20090.023), a preoperative inotropic score\u2009&gt;\u200910 (OR 8.5; <jats:italic>P<\/jats:italic>\u2009=\u20090.0001), and preoperative ECMO support (OR 4.2; <jats:italic>P<\/jats:italic>\u2009=\u20090.012). For donors, the predictive risk factor was a donor score\u2009\u2265\u200917 (OR 8.3; <jats:italic>P<\/jats:italic>\u2009=\u20090.006). The absence of EGF was correlated with improved long\u2010term survival: 94% at 1 year and 81% at 5 years without EGF versus 76% and 36% at 1 year (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and 70% and 28% at 5 years (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with EGF requiring IABP and ECMO support, respectively. In\u2010hospital weaned and survived patients after IABP or ECMO treatment for moderate\u2010to\u2010severe EGF had a similar 5\u2010year conditional survival rate as transplant patients who had not suffered EGF: 88% without EGF versus 84% with EGF treated with mechanical circulatory support devices (<jats:italic>P<\/jats:italic>\u2009=\u20090.08). The occurrence of EGF is a multifactorial deleterious event that depends on donor and recipient profiles. IABP and ECMO support are reliable treatment strategies, depending on the grade of EGF. Furthermore, surviving patients treated with IABP or ECMO have the same long\u2010term conditional survival rate as patients who have not suffered EGF.<\/jats:p>","DOI":"10.1111\/aor.12793","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T01:55:27Z","timestamp":1471398927000},"source":"Crossref","is-referenced-by-count":22,"title":["Role of Intra\u2010Aortic Balloon Pump and Extracorporeal Membrane Oxygenation in Early Graft Failure After Cardiac Transplantation"],"prefix":"10.1111","volume":"40","author":[{"given":"Antonio","family":"Loforte","sequence":"first","affiliation":[{"name":"Departments of Cardiovascular Surgery and Transplantation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Murana","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Surgery and Transplantation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Cefarelli","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Surgery and Transplantation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Jafrancesco","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Surgery and Transplantation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Sabatino","sequence":"additional","affiliation":[{"name":"Cardiology and Transplantation, S. Orsola-Malpighi Hospital, Bologna University Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Martin Suarez","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Surgery and Transplantation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Pilato","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Surgery and Transplantation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Pacini","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Surgery and Transplantation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Grigioni","sequence":"additional","affiliation":[{"name":"Cardiology and Transplantation, S. Orsola-Malpighi Hospital, Bologna University Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Di","family":"Bartolomeo","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Surgery and Transplantation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Marinelli","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Surgery and Transplantation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.02.027"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.08.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.06.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.01.728"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12317"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.07.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659112443722"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2007.00337.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000353"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.11.005"},{"key":"e_1_2_7_12_1","first-page":"343","article-title":"Extra\u2010corporeal membrane oxygenation temporary support for early graft failure after cardiac transplantation","volume":"37","author":"D'Alessandro C","year":"2010","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.05.066"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.04.059"},{"key":"e_1_2_7_15_1","first-page":"1348","article-title":"Steering Group of the UK Cardiothoracic Transplant Audit. Incidence and outcome of Levitronix CentriMag support as rescue therapy for early cardiac allograft failure: a United Kingdom national study","volume":"40","author":"Thomas HL","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000117"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340101006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.05.018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2011.01423.x"},{"key":"e_1_2_7_20_1","first-page":"971","article-title":"Reversibility of fixed pulmonary hypertension in left ventricular assist device support recipients","volume":"40","author":"Mikus E","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.04.010"},{"key":"e_1_2_7_22_1","first-page":"962","article-title":"Predictive risk factors for primary graft failure requiring temporary extra\u2010corporeal membrane oxygenation support after cardiac transplantation in adults","volume":"40","author":"D'Alessandro C","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.08.004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs113"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.08.003"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60261-6"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12793","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12793","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:25:46Z","timestamp":1695507946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/aor.12793"],"URL":"https:\/\/doi.org\/10.1111\/aor.12793","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}