{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:37:31Z","timestamp":1769863051550,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T00:00:00Z","timestamp":1479772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Significant mitral regurgitation (MR) is thought to decrease after left ventricular assist device (LVAD) implantation, and therefore repair of mitral valve is not indicated in current practice. However, residual moderate and severe MR leads to pulmonary artery pressure increase, thereby resulting in right ventricular (RV) dysfunction during follow\u2010up. We examined the impact of residual MR on systolic function of the right ventricle by echocardiography after LVAD implantation. This study included 90 patients (mean age: 51.7\u2009\u00b1\u200910.9 years, 14.4% female) who underwent LVAD implantation (HeartMate II\u2009=\u200921, HeartWare\u2009=\u200969) in a single center between December 2010 and June 2014. Echocardiograms obtained at 3\u20136 months and over after implantation were analyzed retrospectively. RV systolic function was graded as normal, mild, moderate, and severely depressed. MR (\u2265moderate) was observed in 43 and 44% of patients at early and late period, respectively. Systolic function of the RV was severely depressed in 16 and 9% of all patients. Initial analysis (mean duration of support 174.3\u2009\u00b1\u200942.5 days) showed a statistically significant correlation between less MR and improved systolic function of RV (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). Secondary echocardiographic analysis (following a mean duration of support of 435.1\u2009\u00b1\u2009203 days) was also statistically significant for MR degree and RV systolic dysfunction (<jats:italic>P<\/jats:italic>\u2009=\u20090.008). Residual MR after LVAD implantation may cause deterioration of RV systolic function and cause right\u2010sided heart failure symptoms. Repair of severe MR, in selected patients such as those with severe pulmonary hypertension and depressed RV, may be considered to improve the patient's clinical course during pump support.<\/jats:p>","DOI":"10.1111\/aor.12831","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T05:38:53Z","timestamp":1479793133000},"page":"622-627","source":"Crossref","is-referenced-by-count":25,"title":["Impact of Residual Mitral Regurgitation on Right Ventricular Systolic Function After Left Ventricular Assist Device Implantation"],"prefix":"10.1111","volume":"41","author":[{"given":"Serkan","family":"Ertugay","sequence":"first","affiliation":[{"name":"Cardiovascular Surgery Ege University Faculty of Medicine \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice S.","family":"Kemal","sequence":"additional","affiliation":[{"name":"Cardiology Near East University Faculty of Medicine Nicosia Turkish Republic of Northern Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Erzincan Mengucek Gazi University Erzincan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catagay","family":"Engin","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Ege University Faculty of Medicine \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanem","family":"Nalbantgil","sequence":"additional","affiliation":[{"name":"Cardiology Ege University Faculty of Medicine \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahir","family":"Yagdi","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Ege University Faculty of Medicine \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Ozbaran","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Ege University Faculty of Medicine \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.05.044"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.10.024"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.098"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12100"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.12.022"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.11.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.052"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.04.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Recommendations 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