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Our aim was to assess the ability of a newly refined EVE system to maintain key physiological parameters in preterm lambs within optimal ranges for 48 h. EVE group; <jats:italic>n<\/jats:italic>\u2009=\u20096: Preterm lambs were delivered under general anesthesia at 115\u2009\u00b1\u20092 days of gestational age. Animals were submerged in a bath of artificial amniotic fluid on EVE therapy for 48 h. Physiological parameters were monitored in real\u2010time over the length of the experiment. Control group; <jats:italic>n<\/jats:italic>\u2009=\u200911: Ewes carrying a single fetus (115\u2009\u00b1\u20092 days of gestational age) underwent recovery surgery to allow placement of a fetal carotid artery catheter. Fetuses received an infusion of sterile saline only. After euthanasia, EVE and Control group fetuses underwent necroscopy to perform static pressure\u2013volume curves and for sampling of lung and cord blood plasma for molecular analyses. Five out of six fetuses in the EVE group completed the study period with key physiological variables remaining within their respective reference ranges for the duration of the 48 h study. Bacteremia was identified in four out of five EVE fetuses, and was associated with a systemic inflammatory response. Using our refined EVE therapy platform, preterm lambs were maintained in a stable physiological condition for 48 h. These findings represent a significant advance over earlier work with this system; however, the identification of bacteremia and a fetal inflammatory response suggests that further refinement to the EVE therapy platform is required.<\/jats:p>","DOI":"10.1111\/aor.12974","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T06:56:39Z","timestamp":1505112999000},"page":"959-968","source":"Crossref","is-referenced-by-count":26,"title":["Stable Control of Physiological Parameters, But Not Infection, in Preterm Lambs Maintained on Ex Vivo Uterine Environment Therapy"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6693-4119","authenticated-orcid":false,"given":"Yuichiro","family":"Miura","sequence":"first","affiliation":[{"name":"School of Women's and Infants\u2019 Health The University of Western Australia Crawley Western Australia Australia"},{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Usuda","sequence":"additional","affiliation":[{"name":"School of Women's and Infants\u2019 Health The University of Western Australia Crawley Western Australia Australia"},{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimpei","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Woodward","sequence":"additional","affiliation":[{"name":"School of Women's and Infants\u2019 Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"School of Women's and Infants\u2019 Health The University of Western Australia Crawley Western Australia Australia"},{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle C.","family":"Musk","sequence":"additional","affiliation":[{"name":"Animal Care Services The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhas G.","family":"Kallapur","sequence":"additional","affiliation":[{"name":"School of Women's and Infants\u2019 Health The University of Western Australia Crawley Western Australia Australia"},{"name":"Neonatology Continuing Medical Education Global Health Center Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Kitanishi","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Newnham","sequence":"additional","affiliation":[{"name":"School of Women's and Infants\u2019 Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Stock","sequence":"additional","affiliation":[{"name":"School of Women's and Infants\u2019 Health The University of Western Australia Crawley Western Australia Australia"},{"name":"Centre for Reproductive Health, Queens Institute for Medical Research University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Kemp","sequence":"additional","affiliation":[{"name":"School of Women's and Infants\u2019 Health The University of Western Australia Crawley Western Australia Australia"},{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization. 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