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In the current study, we selected and implemented six of the most promising physiological controllers presented in literature. We tuned the controllers for the same objectives by using the loop\u2010shaping method from control theory. The in vitro experiments were derived from literature and included different preload, afterload, and contractility variations. All experiments were repeated with an increased or decreased contractility from the baseline pathological circulation and with simulated sensor drift. The controller performances were compared with an LVAD operated at constant speed (CS) and a physiological circulation. During preload variations, all controllers resulted in a pump flow change that resembled the cardiac output response of the physiological circulation. For afterload variations, the response varied among the controllers, whereas some of them presented a high sensitivity to contractility or sensor drift, leading to LV suction and overload. In such cases, the need for recalibration of the controllers or the sensor is indicated. Preload\u2010based physiological controllers showed their clinical significance by outperforming the CS operation and promise many benefits for the LVAD therapy. However, their clinical implementation in the near future for long\u2010term use is highly dependent on the sensor technology and its reliability.<\/jats:p>","DOI":"10.1111\/aor.12999","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T07:02:50Z","timestamp":1509606170000},"source":"Crossref","is-referenced-by-count":52,"title":["Standardized Comparison of Selected Physiological Controllers for Rotary Blood Pumps: In Vitro Study"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8755-5003","authenticated-orcid":false,"given":"Anastasios","family":"Petrou","sequence":"first","affiliation":[{"name":"Department of Mechanical and Process Engineering, Product Development Group Zurich ETH Zurich  Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongseok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Process Engineering, Product Development Group Zurich ETH Zurich  Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seraina","family":"Dual","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Process Engineering, Product Development Group Zurich ETH Zurich  Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Ochsner","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Process Engineering, Product Development Group Zurich ETH Zurich  Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Meboldt","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Process Engineering, Product Development Group Zurich ETH Zurich  Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Schmid Daners","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Process Engineering, Product Development Group Zurich ETH Zurich  Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.10.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2007.00420.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/34\/1\/R1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-016-1552-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2002.07126.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12654"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121413"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2010.01066.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12225"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12820"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.09.008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/MAT.0000000000000477","article-title":"Clinical implications of physiological flow adjustment in continuous\u2010flow left ventricular assist devices","volume":"63","author":"Tchantchaleishvili V","year":"2016","journal-title":"ASAIO J"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000533"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12370"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12303"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2012.2230000"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31805b7e39"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","unstructured":"OchsnerG AmacherR Schmid DanersM Emulation of ventricular suction in a hybrid mock circulation.Proc. 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