{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:56:26Z","timestamp":1777571786004,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:00:00Z","timestamp":1511395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Sciences and Engineering Research Council (NSERC) of Canada, Ottawa","award":["343165"],"award-info":[{"award-number":["343165"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mitral valve percutaneous edge\u2010to\u2010edge repair (PEtER) is a viable solution in high\u2010risk patients with severe symptomatic mitral regurgitation. However, the generated double\u2010orifice configuration poses challenges for the evaluation of the hemodynamic performance of the mitral valve and may alter flow patterns in the left ventricle (LV) during diastole. This in vitro study aims to evaluate the hemodynamic modifications following a simulated PEtER. A custom\u2010made mitral valve was developed, and two configurations were tested: (i) a single\u2010orifice valve with mitral regurgitation and (ii) a double\u2010orifice mitral valve configuration following PEtER. The hemodynamic performance of the valve was evaluated using Doppler echocardiography and catheterization, while the flow patterns in the LV were investigated using particle image velocimetry (PIV). The tests were run at a stroke volume of 65 mL and a heart rate of 70 bpm. PEtER was found to significantly reduce the regurgitant volume (15 vs. 34 mL). There was a good agreement between Doppler and catheter transmitral pressure gradients (peak gradient: 9 vs. 7 mm Hg; mean gradient: 4 vs. 3 mm Hg) as well as an excellent agreement between maximal velocity measured by Doppler and PIV (1.60 vs. 1.58 m\/s). Vortex development in the LV during diastole was significantly different after repair. PEtER significantly increased the amplitude of Reynolds and viscous shear stresses, as well as the number of high shear regions in the LV, potentially promoting thromboembolism events.<\/jats:p>","DOI":"10.1111\/aor.13020","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T09:26:45Z","timestamp":1511429205000},"page":"516-524","source":"Crossref","is-referenced-by-count":14,"title":["Experimental Investigation of Left Ventricular Flow Patterns After Percutaneous Edge\u2010to\u2010Edge Mitral Valve Repair"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8990-6391","authenticated-orcid":false,"given":"Morteza","family":"Jeyhani","sequence":"first","affiliation":[{"name":"Department of Mechanical and Industrial Engineering Ryerson University Toronto Ontario Canada"},{"name":"Department of Mechanical and Industrial Engineering Concordia University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrokh","family":"Shahriari","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Industrial Engineering University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Labrosse","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Ottawa Ottawa Ontario 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