{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:51:20Z","timestamp":1791978680693,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute interstitial pneumonia (AIP) is a rare idiopathic interstitial lung disease with rapid progressive respiratory failure and high mortality. In the present report, three cases of AIP complicated by refractory respiratory failure supported with extracorporeal membrane oxygenation (ECMO) are presented. One male and two female patients (ages 27\u201359) were included. Venovenous ECMO support was provided using miniaturized systems, with two\u2010site femoro\u2010jugular circuit configuration. Despite lung protective ventilation, prone position and neuromuscular blockade, refractory respiratory failure of unknown etiology supervened (ratio of arterial oxygen partial pressure to fractional inspired oxygen 46\u2013130) and ECMO was initiated after 3\u20137 days of mechanical ventilation. AIP diagnosis was established after exclusion of infectious and noninfectious acute respiratory distress syndrome on the basis of clinical and analytical data, bronchoalveolar lavage analysis and lung imaging, with a confirmatory surgical lung biopsy revealing diffuse alveolar damage of unknown etiology. Immunosuppressive treatment consisted in high\u2010dose corticosteroids and cyclophosphamide in one case. Two patients survived to hospital discharge. ECMO allowed AIP diagnosis and treatment in the presence of refractory respiratory failure, therefore reducing ventilator\u2010induced lung injury and bridging lung recovery in two patients. ECMO referral should be considered in refractory respiratory failure if AIP is suspected.<\/jats:p>","DOI":"10.1111\/aor.13075","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T11:08:53Z","timestamp":1515668933000},"page":"569-574","source":"Crossref","is-referenced-by-count":16,"title":["Extracorporeal Membrane Oxygenation for Refractory Severe Respiratory Failure in Acute Interstitial Pneumonia"],"prefix":"10.1111","volume":"42","author":[{"given":"Gabriela","family":"Gon\u00e7alves\u2010Venade","sequence":"first","affiliation":[{"name":"Department of Emergency and Intensive Care Medicine Centro Hospitalar S. Jo\u00e3o Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Lacerda\u2010Pr\u00edncipe","sequence":"additional","affiliation":[{"name":"Department of Emergency and Intensive Care Medicine Centro Hospitalar S. Jo\u00e3o Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-2943","authenticated-orcid":false,"suffix":"Jr","given":"Roberto","family":"Roncon\u2010Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Emergency and Intensive Care Medicine Centro Hospitalar S. Jo\u00e3o Porto Portugal"},{"name":"Department of Surgery and Physiology, Faculty of Medicine University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Artur","family":"Paiva","sequence":"additional","affiliation":[{"name":"Department of Emergency and Intensive Care Medicine Centro Hospitalar S. Jo\u00e3o Porto Portugal"},{"name":"Department of Medicine, Faculty of Medicine University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"154","article-title":"Fulminating diffuse interstitial fibrosis of the lungs","volume":"51","author":"Hamman L","year":"1935","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62187-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2004.07.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200011000-00003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.3.753"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1325158"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct1103720"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70197-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61069-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1535"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2301-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1471"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201511-2184ED"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201508-1701OC"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000257325.88144.30"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214103"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318188af7a"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00150-2015"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.13075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.13075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:19:38Z","timestamp":1695475178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.13075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,11]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/aor.13075"],"URL":"https:\/\/doi.org\/10.1111\/aor.13075","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,11]]}}}