{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:44:40Z","timestamp":1790675080595,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T00:00:00Z","timestamp":1518393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Following implantation of a left ventricular assist device (LVAD), acceptable functional performance is now being achieved; however, peak VO<jats:sub>2<\/jats:sub> and peak work load (watts) remain considerably limited. Maximum physical capacity is essentially dependent on generated cardiac output (CO) and arteriovenous oxygen difference (avDO<jats:sub>2<\/jats:sub>). We investigated the changes in CO and avDO<jats:sub>2<\/jats:sub> during exercise in LVAD patients with an HVAD pump (HeartWare Inc., Framingham, MA, USA). Approximately 6 weeks after implantation, 20 patients (100% male, 60.8\u2009\u00b1\u20097.3 years old, BMI 25.7\u2009\u00b1\u20093.3) underwent a six\u2010minute walk test (6MWT), a cardiopulmonary exercise test (CPET), and noninvasive hemodynamic measurement. The mean six\u2010minute walking distance (6MWD) was 403 m (68% of predicted), and mean peak VO<jats:sub>2<\/jats:sub> was 10.9 mL\/kg\/min (39% of predicted). Mean total CO improved from 3.8 L at rest to 7.0 L at maximum exercise. The mean avDO<jats:sub>2<\/jats:sub> increased from 7.4 mL\/dL (44% of oxygen content) at rest to 13.2 mL\/dL (75% of oxygen content) at maximum exercise. There was a significant increase in both total CO (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and avDO<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) between rest and sub\u2010maximum exercise. As exercise levels increased, however, no further significant changes were achieved. Long\u2010term studies, especially in combination with exercise programs, would be desirable in order to observe the development of these parameters.<\/jats:p>","DOI":"10.1111\/aor.13102","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T04:59:13Z","timestamp":1518497953000},"page":"686-694","source":"Crossref","is-referenced-by-count":20,"title":["Changes in Total Cardiac Output and Oxygen Extraction During Exercise in Patients Supported With an HVAD Left Ventricular Assist Device"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4977-8414","authenticated-orcid":false,"given":"Thomas","family":"Schmidt","sequence":"first","affiliation":[{"name":"Sch\u00fcchtermann\u2010Klinik Bad Rothenfelde, Bad Rothenfelde Cologne Germany"},{"name":"Department for Preventive and Rehabilitative Sport and Exercise Medicine Institute for Cardiology and Sports Medicine, German Sports University Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birna","family":"Bjarnason\u2010Wehrens","sequence":"additional","affiliation":[{"name":"Department for Preventive and Rehabilitative Sport and Exercise Medicine Institute for Cardiology and Sports Medicine, German Sports University Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Mommertz","sequence":"additional","affiliation":[{"name":"Sch\u00fcchtermann\u2010Klinik Bad Rothenfelde, Bad Rothenfelde Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Hannig","sequence":"additional","affiliation":[{"name":"Sch\u00fcchtermann\u2010Klinik Bad Rothenfelde, Bad Rothenfelde Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schulte\u2010Eistrup","sequence":"additional","affiliation":[{"name":"Sch\u00fcchtermann\u2010Klinik Bad Rothenfelde, Bad Rothenfelde Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlev","family":"Willemsen","sequence":"additional","affiliation":[{"name":"Sch\u00fcchtermann\u2010Klinik Bad Rothenfelde, Bad Rothenfelde Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Reiss","sequence":"additional","affiliation":[{"name":"Sch\u00fcchtermann\u2010Klinik Bad Rothenfelde, Bad Rothenfelde Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61889-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.01.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/erd.11.9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.11.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.12.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12936"},{"key":"e_1_2_8_10_1","first-page":"22","volume-title":"Exercise Physiology: Human Bioenergetics and Its Applications","author":"Brooks GA","year":"2005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000529"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.11.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.193698"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.12.112"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.06.007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.958041"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2011.01227.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr069"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9710086"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2015.01.022"},{"key":"e_1_2_8_23_1","first-page":"223","article-title":"Praxisleitlinien Ergometrie","volume":"40","author":"Wonisch M","year":"2014","journal-title":"J f\u00fcr Kardiol"},{"key":"e_1_2_8_24_1","first-page":"585","volume-title":"Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications","author":"Wasserman K.","year":"2005"},{"key":"e_1_2_8_25_1","first-page":"259","volume-title":"Clinical Exercise Testing","author":"Jones NL.","year":"1997"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw180"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.005"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1225340"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/cs1020247","article-title":"Non\u2010invasive measurement of cardiac output in heart failure patients using a new foreign gas rebreathing technique","volume":"102","author":"Gabrielsen A","year":"2002","journal-title":"Clin Sci"},{"key":"e_1_2_8_30_1","first-page":"2125","article-title":"Blood pressure management in mechanical circulatory support","volume":"7","author":"Bennett MK","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.2.599"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.06.011"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.052"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.02.021"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.083"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12172"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487314558772"},{"key":"e_1_2_8_38_1","unstructured":"HeartWare Inc. HeartWare Ventricular Assist System \u2010 Instructions for Use. Available at:http:\/\/www.heartware.com\/sites\/default\/files\/uploads\/docs\/ifu00001_rev_15.pdf. Accessed April 17 2017."},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq086"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001825"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.4.769"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103636"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00224.2006"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2011.02341.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01632.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3181838f70"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340308784245757"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.04.008"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-014-0155-9"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.06.020"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.13102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.13102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T01:23:12Z","timestamp":1695000192000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.13102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,12]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/aor.13102"],"URL":"https:\/\/doi.org\/10.1111\/aor.13102","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,12]]}}}