{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T18:51:44Z","timestamp":1792349504934,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Retinal prosthesis or artificial retina is a promising modality of treatment for outer retinal degeneration, caused by primary and secondary loss of photoreceptor cells, in hereditary retinal dystrophy and age\u2010related macular degeneration, respectively. Okayama University\u2010type retinal prosthesis (OUReP) is a photoelectric dye\u2010coupled polyethylene film which generates electric potential in response to light and stimulates nearby neurons. The dye\u2010coupled films were implanted by vitreous surgery in the subretinal space of monkey eyes with macular degeneration which had been induced by cobalt chloride injection from the scleral side. A pilot 1\u2010month observation study involved 6 monkeys and a pivotal 6\u2010month observation study involved 8 monkeys. Of 8 monkeys in 6\u2010month group, 3 monkeys underwent dye\u2010coupled film removal at 5 months and were observed further for 1 month. The amplitude of visual evoked potential which had been reduced by macular degeneration did recover at 1 month after film implantation and maintained the level at 6 months. Optical coherence tomography showed no retinal detachment, and full\u2010field electroretinograms maintained a\u2010wave and b\u2010wave amplitudes, indicative of no retinal toxicity. Pathological examinations after 6\u2010month implantation showed structural integrity of the inner retinal layer in close apposition to dye\u2010coupled films. The implanted films which were removed by vitrectomy 5 months later showed light\u2010evoked surface electric potentials by scanning Kelvin probe measurement. The photoelectric dye\u2010coupled film (OUReP), which serves as a light\u2010receiver and a displacement current generator in the subretinal space of the eye, has a potential for recovering vision in diseases with photoreceptor cell loss, such as retinitis pigmentosa and age\u2010related macular degeneration.<\/jats:p>","DOI":"10.1111\/aor.13120","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:36:10Z","timestamp":1523320570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Visual Evoked Potential Recovery by Subretinal Implantation of Photoelectric Dye\u2010Coupled Thin Film Retinal Prosthesis in Monkey Eyes With Macular Degeneration"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-0030","authenticated-orcid":false,"given":"Toshihiko","family":"Matsuo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Okayama University Medical School and Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Polymer Materials Science Okayama University Faculty of Engineering and Graduate School of Natural Science and Technology Okayama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Center for Innovative Clinical Medicine Okayama University Hospital Okayama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Polymer Materials Science Okayama University Faculty of Engineering and Graduate School of Natural Science and Technology Okayama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Orthodontist Okayama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Shin Nippon Biomedical Laboratories, Ltd. 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