{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:24:02Z","timestamp":1788236642805,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672186"],"award-info":[{"award-number":["81672186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aseptic loosening due to wear particle\u2010induced osteolysis is the main cause of arthroplasty failure and the influence of postmenopausal osteoporosis and anti\u2010osteoporosis treatment on Titanium (Ti) particle\u2010induced osteolysis remains unclear. 66 C57BL\/6J female mice were used in this study. Ovariectomy (OVX) was performed to induce osteopenia mice and confirmed by micro\u2010CT. The Ti particle\u2010induced mouse calvaria osteolysis model was established subsequently and both OVX and Sham\u2010OVX mice were divided into four groups, respectively: Ti (\u2010) group, Ti group, Ti + zoledronic acid (ZOL) group (50ug\/kg, local administration, single dose) and Ti + teriparatide (TPTD) group (40ug\/kg\/d, subcutaneous injection*14d). Mice calvarias were collected for micro\u2010CT and histomorphometric analysis 2 weeks after particle induction. 8 weeks after bilateral OVX, significantly reduced BMD and microstructure parameters in both proximal tibia and calvaria were observed in OVX mice when comparing with Sham\u2010OVX mice. OVX mice in Ti group had not only markly decreased BMD and BV\/TV, but also significantly increased total porosity, eroded surface area and osteoclast numbers when comparing with Sham\u2010OVX mice. Shown by Two\u2010way ANOVA analysis, the interaction terms between OVX and Ti implantation on micro\u2010CT and histomorphometry parameters didn\u2019t reach significant difference. As illustrated by micro\u2010CT and histological analysis, ZOL treatment markedly inhibited Ti particle\u2010induced osteolysis in OVX mice and Sham\u2010OVX mice, and there were significant differences when comparing to both Ti and Ti+TPTD group. The combination of osteoporosis and Ti particle implantation result in aggravated bone resorption, accompanied with increased osteoclasts and excessive inflammation response. ZOL was more effective in preventing Ti particle\u2010induced osteolysis in both OVX mice and Sham\u2010OVX mice than TPTD in short\u2010term administration. ZOL exert the protective effects on Ti particle\u2010induced bone loss via the suppression of osteoclasts.<\/jats:p>","DOI":"10.1111\/aor.13271","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T07:04:30Z","timestamp":1539241470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antiresorptive Agents are More Effective in Preventing Titanium Particle\u2010Induced Calvarial Osteolysis in Ovariectomized Mice Than Anabolic Agents in Short\u2010Term Administration"],"prefix":"10.1111","volume":"42","author":[{"given":"Guangtao","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University, Yuexiu District Guangzhou Guangdong Province People's Republic of 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Malignant Tumor Epigenetics and Gene Regulation Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University, Yuexiu District Guangzhou Guangdong Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/575936"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.3.251"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.55095\/achot2015\/008","article-title":"The incidence of osteopenia and osteoporosis in patients with cementless total hip arthroplasty","volume":"82","author":"Lacko M","year":"2015","journal-title":"Acta Chir Orthop Traumatol Cech"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200209000-00013"},{"key":"e_1_2_9_6_1","first-page":"93","article-title":"Revision primary total hip replacement: causes and 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