{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:07:28Z","timestamp":1787947648224,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T00:00:00Z","timestamp":1534032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>The aim of this systematic review and meta\u2010analysis was to evaluate the outcomes of concomitant mitral valve surgery for significant preexisting mitral regurgitation (MR) in patients undergoing continuous\u2010flow left ventricular assist device (CF\u2010LVAD) implantation. Electronic search was performed to identify all studies in the English literature examining concurrent mitral valve surgery in patients with CF\u2010LVAD implantation. Identified articles were systematically assessed for inclusion and exclusion criteria. Of 2319 studies identified, 8 studies were included. Among 445 patients with moderate to severe or severe MR, 113 (25.4%) patients received concurrent mitral valvular intervention during CF\u2010LVAD implantation. There were no significant differences in cardiopulmonary bypass time (MR Surgery 154 min vs. no MR Surgery 119 min, <jats:italic>P<\/jats:italic> = 0.64) or hospital length of stay (MR Surgery 21 days vs. no MR Surgery 18 days, <jats:italic>P<\/jats:italic> = 0.93). On follow\u2010up, there were no significant differences in freedom from greater than moderate MR (MR Surgery 100% vs. no MR Surgery 74%, <jats:italic>P<\/jats:italic> = 0.12) or left ventricular end\u2010diastolic diameter (MR Surgery: 60 mm vs. no MR Surgery 65 mm, <jats:italic>P<\/jats:italic> = 0.51). Survival was comparable at 6\u2010months (MR Surgery 77% vs. no MR Surgery 81%, <jats:italic>P<\/jats:italic> = 0.75), 1\u2010year (MR Surgery 72% vs. no MR Surgery 80%, <jats:italic>P<\/jats:italic> = 0.36), and 2\u2010years of follow\u2010up (MR Surgery 65% vs. no MR Surgery 70%, <jats:italic>P<\/jats:italic> = 0.56). The results of our systematic review and meta\u2010analysis of 8 studies consisting of 445 patients demonstrates that the addition of mitral valve intervention to CF\u2010LVAD implantation appears to be safe with comparable survival to those undergoing CF\u2010LVAD implantation alone. Large prospective randomized clinical trials are needed to elucidate whether concomitant mitral valve intervention during CF\u2010LVAD implantation in patients with severe MR is necessary.<\/jats:p>","DOI":"10.1111\/aor.13295","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T06:28:29Z","timestamp":1534141709000},"page":"1139-1147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Impact of Concomitant Mitral Valve Surgery With LVAD Placement: Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4975-5140","authenticated-orcid":false,"given":"Jae H.","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery Thomas Jefferson University  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3567-3796","authenticated-orcid":false,"given":"Jessica G.Y.","family":"Luc","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Department of Surgery University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Moncho Escriv\u00e1","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Phan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed S. A.","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Thomas Jefferson University  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinal","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Thomas Jefferson University  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Entwistle","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Thomas Jefferson University  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohinton J.","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Thomas Jefferson University  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. T.","family":"Massey","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Thomas Jefferson University  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vakhtang","family":"Tchantchaleishvili","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Thomas Jefferson University  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067758"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.08.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.044"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.111.963991"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.01.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31826e4267"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12100"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.12.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.10.024"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02479-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.05.018"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2011.05.047"},{"key":"e_1_2_9_14_1","first-page":"Ii309","article-title":"Influence of left ventricular assist on valvular regurgitation","volume":"88","author":"Holman WL","year":"1993","journal-title":"Circulation"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-199407000-00041"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31829ff57d"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31829be026"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.11.023"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.06.078"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivx223"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2008.08.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.09.014"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12831"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.03.006"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.13295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.13295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:04:45Z","timestamp":1694664285000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.13295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/aor.13295"],"URL":"https:\/\/doi.org\/10.1111\/aor.13295","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,12]]},"assertion":[{"value":"2018-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}