{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:47:08Z","timestamp":1783345628731,"version":"3.54.6"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our aim was to study the feasibility of implanting the Infant Jarvik 2015 in patients weighing less than 8\u00a0kg. The Infant Jarvik 2015 left ventricular assist device (LVAD) was tested in a hybrid simulator of the cardiovascular system reproducing specific patients\u2019 hemodynamics for different patient weights (2\u20137\u00a0kg). For each weight, the sensitivity of the pump to different circulatory parameters (peripheral resistance, left ventricular elastance, right ventricular elastance, heart rate, and heart filling characteristics) has been tested repeating for each experiment a pump ramp (10\u00a0000\u201318\u00a0000\u00a0rpm). The increase in the pump speed causes a decrease (increase) in the left (right) atrial pressure, an increase (decrease) in the arterial systemic (pulmonary) pressure, an increase in the right ventricular pressure, a decrease (increase) in the left (right) ventricular volume, a decrease in the left ventricular cardiac output, an increase in the LVAD output and an increase in the right ventricular cardiac output (total cardiac output). Suction was observed for lower weight patients and for higher pump speed in the case of vasodilation, left ventricular recovery, bradycardia, right ventricular failure, and left ventricular hypertrophy. Backflow was observed in the case of left ventricular recovery at lower pump speed. In the hybrid simulator, the Infant Jarvik 2015 could be suitable for the implantation in patients lower than 8\u00a0kg because of the stability of the device respect to the cardio\/circulatory changes (low frequency of suction and backflow) and because of the capability of the device to maintain adequate patient hemodynamics.<\/jats:p>","DOI":"10.1111\/aor.13302","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T12:22:30Z","timestamp":1541506950000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Is the New Infant Jarvik 2015 Suitable for Patients&lt;8 kg? In Vitro Study Using a Hybrid Simulator"],"prefix":"10.1111","volume":"43","author":[{"given":"Arianna","family":"Di Molfetta","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Policlinico Gemelli Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Zielinski","sequence":"additional","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering PAS Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering PAS Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macej","family":"Kozarski","sequence":"additional","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering PAS Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4389-9728","authenticated-orcid":false,"given":"Piotr","family":"Okrzeja","sequence":"additional","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering PAS Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0452-3453","authenticated-orcid":false,"given":"Roberta","family":"Iacobelli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Cardiac Surgery Pediatric Hospital Bambino Ges\u00f9 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Filippelli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Cardiac Surgery Pediatric Hospital Bambino Ges\u00f9 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Perri","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Policlinico Gemelli Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Darowski","sequence":"additional","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering PAS Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Massetti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Policlinico Gemelli Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jarvik","sequence":"additional","affiliation":[{"name":"Jarvik Heart, Inc. New York, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Amodeo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Cardiac Surgery Pediatric Hospital Bambino Ges\u00f9 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S82379"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00614"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2016.09.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.12.070"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12178"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139880302600109"},{"key":"e_1_2_7_8_1","first-page":"605","article-title":"A hybrid (hydro\u2010numerical) circulatory model: investi\u2010gations of mechanical aortic valves and a numerical valve model","volume":"63","author":"Kozarski M","year":"2015","journal-title":"Bull Pol Acad Sci\u2010Tech Sci"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12929"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000168"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000152"},{"key":"e_1_2_7_12_1","first-page":"3318","article-title":"Detection of ventricular suction in an implantable rotary blood pump using support vector machines","volume":"2011","author":"Wang Y","year":"2011","journal-title":"Conf Proc IEEE Eng Med Biol Soc"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.13302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.13302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T17:34:10Z","timestamp":1694540050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.13302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,6]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/aor.13302"],"URL":"https:\/\/doi.org\/10.1111\/aor.13302","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,6]]},"assertion":[{"value":"2018-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}