{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:21Z","timestamp":1787013861053,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    While pediatric HeartWare HVAD application has increased, determining candidacy and timing for initiation of pediatric VAD support has remained a challenge. We present our experience with a systematic approach to HVAD implantation as a bridge to pediatric heart transplantation. We performed a retrospective, single center review of pediatric patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a011) who underwent HVAD implantation between September 2014 and January 2018. Primary endpoints evaluated were survival to heart transplantation, need for right ventricular assist device (RVAD) at any point, ongoing HVAD support, or death. Median patient age was 11 years (range: 3\u201316). Median BSA was 1.25 m\n                    <jats:sup>2<\/jats:sup>\n                    (range: 0.56\u20132.1).\u00a0Heart failure etiologies requiring support were dilated cardiomyopathy (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a08), myocarditis (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01), congenital mitral valve disease (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01), and single ventricle heart failure (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01). Median time from cardiac ICU admission for heart failure to HVAD placement was 15 days (range 3\u201355), based on standardized VAD implantation criteria involving imaging assessment and noncardiac organ evaluation. The majority of patients (91%) were INTERMACS Level 2 at time of implant. Three patients (27%) had CentriMag RVAD placement at time of HVAD implantation. Two of these three patients had successful RVAD explanation within 2 weeks. Median length of HVAD support was 60 days (range 6\u2013405 days). Among the 11 patients, survival during HVAD therapy to date is 91% (10\/11) with 9 (82%) bridged to heart transplantation and one (9%) continuing to receive support. Posttransplant survival has been 100%, with median follow\u2010up of 573 days\u2009(range 152\u20131126). A systematic approach to HVAD implantation can provide excellent results in pediatric heart failure management for a variety of etiologies and broad BSA range.\n                  <\/jats:p>","DOI":"10.1111\/aor.13344","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T09:10:01Z","timestamp":1533633001000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["HeartWare Ventricular Assist Device Implantation for Pediatric Heart Failure\u2014A Single Center Approach"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-6399","authenticated-orcid":false,"given":"Kristen","family":"Nelson McMillan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Division of Pediatric Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Department of Pediatrics Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narutoshi","family":"Hibino","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Cardiothoracic Surgery Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Wadia","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Division of Pediatric Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Department of Pediatrics Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Division of Pediatric Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Department of Pediatrics Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi","family":"Marshall","sequence":"additional","affiliation":[{"name":"Johns Hopkins Hospital, Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuri","family":"Alvarez\u2010Machado","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Cardiothoracic Surgery Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Alejo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Cardiothoracic Surgery Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Coulson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Ravekes","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca A.","family":"Vricella","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Cardiothoracic Surgery Johns Hopkins University School of Medicine 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