{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:32:22Z","timestamp":1781163142249,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T00:00:00Z","timestamp":1542499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI357"],"award-info":[{"award-number":["KLI357"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Left ventricular assist devices (LVADs) restore cardiovascular circulatory demand at rest with a spontaneous increase in pump flow to exercise. The relevant contribution of cardiac output provided by the LVAD and ejected through the aortic valve for exercises of different intensities has been barely investigated in patients. The hypothesis of this study was that different responses in continuous recorded pump parameters occur for maximal and submaximal intensity exercises and that the pump flow change has an impact on the oxygen uptake at peak exercise (pVO<jats:sub>2<\/jats:sub>). Cardiac and pump parameters such as LVAD flow rate (<jats:italic>Q<\/jats:italic><jats:sub>LVAD<\/jats:sub>), heart rate (HR), and aortic valve (AV) opening were analyzed from continuously recorded LVAD data during physical exercises of maximal (bicycle ergometer test) and submaximal intensities (6\u2010min walk test and regular trainings). During all exercise sessions, the LVAD speed was kept constant. Cardiac and pump parameter responses of 16 patients for maximal and submaximal intensity exercises were similar for <jats:italic>Q<\/jats:italic><jats:sub>LVAD<\/jats:sub>: +0.89\u00a0\u00b1\u00a00.52 versus +0.59\u00a0\u00b1\u00a00.38 L\/min (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.07) and different for HR: +20.4\u00a0\u00b1\u00a015.4 versus +7.7\u00a0\u00b1\u00a05.8\u00a0bpm (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001) and AV\u2010opening with 71% versus 23% of patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Multi\u2010regression analysis with pVO<jats:sub>2<\/jats:sub> (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.77) showed relation to workload normalized by bodyweight (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002), HR response (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.001), AV\u2010opening (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.02), and age (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.06) whereas the change in <jats:italic>Q<\/jats:italic><jats:sub>LVAD<\/jats:sub> was irrelevant. Constant speed LVADs provide inadequate support for maximum intensity exercises. AV\u2010opening and improvements in HR show an important role for higher exercise capacities and reflect exercise intensities. Changes in pump flow do not impact pVO<jats:sub>2<\/jats:sub> and are independent of AV\u2010opening and response in HR. An LVAD speed control may lead to adequate left ventricular support during strenuous physical activities.<\/jats:p>","DOI":"10.1111\/aor.13349","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T06:36:50Z","timestamp":1535611010000},"page":"222-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["LVAD Pump Flow Does Not Adequately Increase With Exercise"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1583-5783","authenticated-orcid":false,"given":"Christoph","family":"Gross","sequence":"first","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna Vienna Austria"},{"name":"Ludwig\u2010Boltzmann\u2010Cluster for Cardiovascular Research Vienna 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Austria"},{"name":"Ludwig\u2010Boltzmann\u2010Cluster for Cardiovascular Research Vienna Austria"},{"name":"Department of Cardiac Surgery Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Schima","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna Vienna Austria"},{"name":"Ludwig\u2010Boltzmann\u2010Cluster for Cardiovascular Research Vienna Austria"},{"name":"Department of Cardiac Surgery Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zimpfer","sequence":"additional","affiliation":[{"name":"Ludwig\u2010Boltzmann\u2010Cluster for Cardiovascular Research Vienna Austria"},{"name":"Department of Cardiac Surgery Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-6615","authenticated-orcid":false,"given":"Francesco","family":"Moscato","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna Vienna Austria"},{"name":"Ludwig\u2010Boltzmann\u2010Cluster for Cardiovascular Research Vienna 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