{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:30:24Z","timestamp":1788582624332,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new extracorporeal circuit for hemodialysis was designed with the goal of improving the middle and high molecular weight toxins removal. A recirculation pathway was added to the hemodialysis circuit and relevant pressure regulation was performed along the circuit in order to keep the ultrafiltration rate as zero. The influence of increasing the recirculation to dialysate flow rate ratio on the removal of urea, vitamin B12, and hemoglobin was investigated. This removal was also modeled by an analytical method and solved by MATLAB software. A significant increase in removal of vitamin B12 (34%) and especially hemoglobin (228%) was achieved using the recirculation flow in an adjusted hemodialysis circuit. The model showed an acceptable agreement with the experimental results which shows its applicability for prediction of different toxin removal in this circuit.<\/jats:p>","DOI":"10.1111\/aor.13355","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T05:55:08Z","timestamp":1536126908000},"page":"254-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Novel Extracorporeal Dialysis Circuit to Improve the Removal Efficiency of High and Middle Molecular Weight Toxins"],"prefix":"10.1111","volume":"43","author":[{"given":"Ali","family":"Poorkhali","sequence":"first","affiliation":[{"name":"Trauma Research Center Baqiyatallah University of Medical Sciences Tehran Iran"},{"name":"Nanobiotechnology Research Center Baqiyatallah University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davood","family":"Bizari","sequence":"additional","affiliation":[{"name":"Trauma Research Center Baqiyatallah University of Medical Sciences Tehran Iran"},{"name":"Nanobiotechnology Research Center Baqiyatallah University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8816-8489","authenticated-orcid":false,"given":"Hasan","family":"Farrokhzad","sequence":"additional","affiliation":[{"name":"Chemical, Polymeric and Petrochemical Technology Development Research Division Research Institute of Petroleum Industry Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.368"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/clinchem\/38.8.1429","article-title":"Assessment of urea and other uremic markers for quantification of dialysis efficacy","volume":"38","author":"Vanholder RC","year":"1992","journal-title":"Clin Chem"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00924.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0762-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs309"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs052"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3383-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358214"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2011.00602.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328960"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346093"},{"key":"e_1_2_6_13_1","first-page":"1023","article-title":"Increasing dialysate flow rate increases dialyzer urea clearance and dialysis efficiency: An in vivo study","volume":"20","author":"Azar AT","year":"2009","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq326"},{"key":"e_1_2_6_15_1","first-page":"639","article-title":"The effect of increasing blood flow rate on dialysis adequacy in hemodialysis patients","volume":"20","author":"Borzou S","year":"2009","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"e_1_2_6_16_1","unstructured":"B.Braun Avitum AG.Hessen: The Company; c2018[Internet]. Available at:https:\/\/www.bbraun.com\/content\/dam\/catalog\/bbraun\/bbraunProductCatalog\/S\/AEM2015\/en-01\/b7\/xevonta.pdf.bb-.46436009\/xevonta.pdf. [Accessed May 24 2018]."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-7388(93)85127-I"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2005.07.025"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2011.01243.x"},{"key":"e_1_2_6_20_1","first-page":"55","article-title":"Red blood cell mechanical stability test","volume":"55","author":"Baskurt OK","year":"2013","journal-title":"Clin Hemorheol Micro"},{"key":"e_1_2_6_21_1","first-page":"311","article-title":"Kinetic study of enzymatic urea hydrolysis in the pH range 4\u20139","volume":"17","author":"Fidaleo M","year":"2003","journal-title":"Chem Biochem Eng Q"},{"key":"e_1_2_6_22_1","first-page":"23","article-title":"Measurement of vitamin B12 concentration: a review on available methods","volume":"2","author":"Karmi O","year":"2011","journal-title":"IIOAB J"},{"key":"e_1_2_6_23_1","volume-title":"Heat and Mass Transfer: Fundamentals & Applications","author":"Cengel YA","year":"2011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2006.08.029"},{"key":"e_1_2_6_25_1","volume-title":"Fundamentals of Heat and Mass Transfer","author":"Bergman TL","year":"2011"},{"key":"e_1_2_6_26_1","first-page":"9","article-title":"Permeate flux in ultrafiltration membrane: a review","volume":"14","author":"Beicha A","year":"2011","journal-title":"J Appl Membrane Sci Technol"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.13355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.13355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.13355","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.13355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T09:21:45Z","timestamp":1694337705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.13355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,15]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/aor.13355"],"URL":"https:\/\/doi.org\/10.1111\/aor.13355","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,15]]},"assertion":[{"value":"2018-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}