{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:56:11Z","timestamp":1790700971393,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The high cost of ventricular assist devices results in poor cost\u2010effectiveness when used as a short\u2010term bridging solution, thus a low\u2010cost alternative is desirable. The present study aimed to develop an intraventricular balloon pump (IVBP) for short\u2010term circulatory support, and to evaluate the effect of balloon actuation timing on the degree of cardiac support provided to a simulated in vitro severe heart failure (SHF) patient. A silicone IVBP was designed to avoid contact with internal left ventricular (LV) features (ie, papillary muscles, chordae, aortic, and mitral valves) based on LV computed tomography data of 10 SHF patients with dilated cardiomyopathy. The hemodynamic effects of varying balloon inflation and deflation timing parameters (inflation duty [D] and end\u2010inflation point [\u03c3]) were evaluated in a purpose\u2010built systemic mock circulatory loop. Three IVBP actuation timing categories were defined: co\u2010, transitional, and counterpulsation. Compared to the SHF baseline, co\u2010pulsation increased aortic flow from 3.5 to 5.2\u00a0L\/min, mean arterial pressure from 72.1 to 94.8\u00a0mmHg and ejection fraction from 14.4% to 21.5%, while mean left atrial pressure decreased from 14.6 to 10\u00a0mmHg. Transitional and counterpulsation resulted in a double ventricular pulse and extended the duration of increased ventricular pressure, potentially impeding diastolic filling and coronary perfusion. This in vitro study showed the IVBP could restore the hemodynamic balance of a simulated SHF patient with dilated cardiomyopathy to healthy levels.<\/jats:p>","DOI":"10.1111\/aor.13454","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T06:24:22Z","timestamp":1552544662000},"page":"860-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of an intraventricular balloon pump for short\u2010term support of patients with heart failure"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5428-3048","authenticated-orcid":false,"given":"Alice C.","family":"Boone","sequence":"first","affiliation":[{"name":"School of Engineering and Built Environment Griffith University Queensland Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-1917","authenticated-orcid":false,"given":"Shaun D.","family":"Gregory","sequence":"additional","affiliation":[{"name":"School of Engineering and Built Environment Griffith University Queensland Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital Brisbane Australia"},{"name":"School of Medicine The University of Queensland Brisbane Australia"},{"name":"Department of Mechanical and Aerospace Engineering Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Wu","sequence":"additional","affiliation":[{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital Brisbane Australia"},{"name":"School of Medicine The University of Queensland Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2271-750X","authenticated-orcid":false,"given":"Andrew","family":"Stephens","sequence":"additional","affiliation":[{"name":"School of Engineering and Built Environment Griffith University Queensland Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital Brisbane Australia"},{"name":"Department of Mechanical and Aerospace Engineering Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-4421","authenticated-orcid":false,"given":"Sam","family":"Liao","sequence":"additional","affiliation":[{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital Brisbane Australia"},{"name":"Department of Mechanical and Aerospace Engineering Monash University Melbourne Australia"},{"name":"Institute of Health and Biomedical Innovation Queensland University of Technology Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4994-5967","authenticated-orcid":false,"given":"Jo P.","family":"Pauls","sequence":"additional","affiliation":[{"name":"School of Engineering and Built Environment Griffith University Queensland Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Salamonsen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventative Medicine Monash University"},{"name":"Intensive Care Unit Alfred Hospital Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fraser","sequence":"additional","affiliation":[{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital Brisbane Australia"},{"name":"School of Medicine The University of Queensland Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff D.","family":"Tansley","sequence":"additional","affiliation":[{"name":"School of Engineering and Built Environment Griffith University Queensland Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital Brisbane 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