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However, thrombus and pannus formations are common complications associated with bileaflet mechanical heart valves. This leads to risks of valve leaflet dysfunction, a life\u2010threatening event. In this experimental study, we investigate, using time\u2010resolved planar particle image velocimetry, the flow characteristics in the ascending aorta in the presence of a dysfunctional bileaflet mechanical heart valve. Several configurations of leaflet dysfunction are investigated and the induced flow disturbances in terms of velocity fields, viscous energy dissipation, wall shear stress, and accumulation of viscous shear stresses are evaluated. We also explore the ability of a new set of parameters, solely based on the analysis of the normalized axial velocity profiles in the ascending aorta, to detect bileaflet mechanical heart valve dysfunction and differentiate between the different configurations tested in this study. Our results show that a bileaflet mechanical heart valve dysfunction leads to a complex spectrum of flow disturbances with each flow characteristic evaluated having its own worst case scenario in terms of dysfunction configuration. We also show that the suggested approach based on the analysis of the normalized axial velocity profiles in the ascending aorta has the potential to clearly discriminate not only between normal and dysfunctional bilealfet heart valves but also between the different leaflet dysfunction configurations. This approach could be easily implemented using phase\u2010contrast MRI to follow up patients with bileaflet mechanical heart valves.<\/jats:p>","DOI":"10.1111\/aor.13483","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T12:47:58Z","timestamp":1557319678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Experimental investigation of the flow downstream of a dysfunctional bileaflet mechanical aortic valve"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-7628","authenticated-orcid":false,"given":"Ahmed","family":"Darwish","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular Fluid Dynamics, Mechanical, Industrial and Aerospace Engineering Concordia University Montreal Quebec 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Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8796-1274","authenticated-orcid":false,"given":"Lyes","family":"Kadem","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Fluid Dynamics, Mechanical, Industrial and Aerospace Engineering Concordia University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"2321","article-title":"Dysfunction of mechanical heart valve prosthesis: experience with surgical management in 48 patients","volume":"7","author":"Ma W\u2010G","year":"2015","journal-title":"J Thorac 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