{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:20:31Z","timestamp":1790428831519,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clot formation within membrane oxygenators (MOs) remains a critical problem during extracorporeal membrane oxygenation (ECMO). The composition of the clots\u2014in particular, the presence of von Willebrand factor (vWF)\u2014may be an indicator for prevalent nonphysiological flow conditions, foreign body reactions, or coagulation abnormalities in critically ill patients. Mats of interwoven gas exchange fibers from randomly collected MOs (PLS, Maquet, Rastatt, Germany) of 21 patients were stained with antibodies (anti\u2010vWF and anti\u2010P\u2010selectin) and counterstained with 4\u2032,6\u2010diamidino\u20102\u2010phenylindole. The extent of vWF\u2010loading was correlated with patient and technical data. While 12 MOs showed low vWF\u2010loadings, 9 MOs showed high vWF\u2010loading with highest accumulations close to crossing points of adjacent gas fibers. The presence and the extent of vWF\u2010fibers\/\u201ccobwebs,\u201d leukocytes, platelet\u2013leukocyte aggregates (PLAs), and P\u2010selectin\u2010positive platelet aggregates were independent of the extent of vWF\u2010loading. However, the highly loaded MOs were obtained from patients with a significantly elevated SOFA score, severe thrombocytopenia, and persistent liver dysfunction. The coagulation abnormalities of these critically ill patients may cause an accumulation of the highly thrombogenic and elongated high\u2010molecular\u2010weight vWF multimers in the plasma which will be trapped in the MOs during the ECMO therapy.<\/jats:p>","DOI":"10.1111\/aor.13513","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T06:24:07Z","timestamp":1560407047000},"page":"1065-1076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Accumulations of von Willebrand factor within ECMO oxygenators: Potential indicator of coagulation abnormalities in critically ill patients?"],"prefix":"10.1111","volume":"43","author":[{"given":"Tamara","family":"Steiger","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery University Medical Center Regensburg Regensburg 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