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This is confounded by the fact that there is currently no direct measure for a proper diagnosis during pump support. Given the severity of this complication and its required treatment, the ability to accurately differentiate CF\u2010LVAD pump thrombosis from other complications is vital. Hemolysis measured by elevated lactate dehydrogenase (LDH) enzyme levels, when there is clinical suspicion of pump\u2010induced thrombosis, is currently accepted as an important metric used by clinicians for diagnosis; however, LDH is a relatively nonspecific finding. LDH exists as five isoenzymes in the body, each with a unique tissue distribution. CF\u2010LVAD pump thrombosis has been associated with elevated serum LDH\u20101 and LDH\u20102, as well as decreased LDH\u20104 and LDH\u20105. Herein, we review the various isoenzymes of LDH and their utility in differentiating hemolysis seen in CF\u2010LVAD pump thrombosis from other physiologic and pathologic conditions as reported in the literature.<\/jats:p>","DOI":"10.1111\/aor.13565","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T14:10:07Z","timestamp":1567951807000},"page":"231-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical implications of LDH isoenzymes in hemolysis and continuous\u2010flow left ventricular assist device\u2010induced thrombosis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1610-7067","authenticated-orcid":false,"given":"Jonathan S.","family":"Gordon","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery Thomas Jefferson University Hospital Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsey T.","family":"Wood","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Thomas Jefferson University Hospital Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3567-3796","authenticated-orcid":false,"given":"Jessica G. 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