{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:04:18Z","timestamp":1784559858075,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to investigate the outcomes of venoarterial extracorporeal life support (VA\u2010ECLS) in a large single\u2010center patient cohort regarding survival and adverse events. Between June 2009 and March 2019, 462 consecutive patients received VA\u2010ECLS. The mean age was 66.2 \u00b1 11.9 years. Two patient groups were identified: Group 1\u2014patients with ECLS due to postcardiotomy shock (PCS) after cardiac surgery (PCS, <jats:italic>n<\/jats:italic> = 357); Group 2\u2014patients with ECLS due to cardiogenic shock (CS) without previous surgery (nonPCS, <jats:italic>n<\/jats:italic> = 105). The primary end point was overall in\u2010hospital survival, while secondary end points were adverse events during the study period. Overall, the in\u2010hospital survival rate was 26%. There was no statistically significant difference between the groups: 26.3% for PCS and 24.8% for nonPCS, respectively (<jats:italic>P<\/jats:italic> &gt; .05). Weaning from VA\u2010ECLS was possible in 44.3% for PCS and in 29.5% for nonPCS (<jats:italic>P<\/jats:italic> = .004). The strong predictors of overall mortality were postoperative hepatic dysfunction (OR = 14.362, 95%CI = 1.948\u2010105.858), cardiopulmonary resuscitation &gt; 30 minutes (OR = 6.301, 95%CI = 1.488\u201026.673), bleeding with a need for revision (OR = 2.123, 95%CI = 1.343\u20103.355), and previous sternotomy (OR = 2.077, 95%CI = 1.021\u20104.223). Despite its low survival rates, VA\u2010ECLS therapy is the last resort and the only lifesaving option for patients in refractory CS. In contrast, there is still a lack of evidence for VA\u2010ECLS in PCS patients. Future studies are warranted to evaluate the outcomes of VA\u2010ECLS therapy after cardiac surgery.<\/jats:p>","DOI":"10.1111\/aor.13625","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T11:19:40Z","timestamp":1577359180000},"page":"620-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical outcomes of venoarterial extracorporeal life support in 462 patients: Single\u2010center experience"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-3736","authenticated-orcid":false,"given":"Konstantin","family":"Zhigalov","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery European Medical School Oldenburg\u2010Groningen, Carl von Ossietzky University Oldenburg Oldenburg Germany"},{"name":"International Thoracic and Cardiovascular Research Association, Website: itcvr.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Pompeu Barros Oliveira","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"International Thoracic and Cardiovascular Research Association, Website: itcvr.com"},{"name":"Division of Cardiovascular Surgery of Pronto Socorro Cardiol\u00f3gico de Pernambuco\u2014PROCAPE University of Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitrii","family":"Safonov","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery European Medical School Oldenburg\u2010Groningen, Carl von Ossietzky University Oldenburg Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilgiz","family":"Zagitov","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery European Medical School Oldenburg\u2010Groningen, Carl von Ossietzky University Oldenburg Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Alofesh","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery European Medical School Oldenburg\u2010Groningen, Carl von Ossietzky University Oldenburg Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varvara","family":"Pavlova","sequence":"additional","affiliation":[{"name":"E.A. Vagner Perm State Medical University Perm Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Easo","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery European Medical School Oldenburg\u2010Groningen, Carl von Ossietzky University Oldenburg Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald C.","family":"Eichstaedt","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery European Medical School Oldenburg\u2010Groningen, Carl von Ossietzky University Oldenburg Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Ennker","sequence":"additional","affiliation":[{"name":"International Thoracic and Cardiovascular Research Association, Website: itcvr.com"},{"name":"School of Medicine, Faculty of Health University of Witten Herdecke Witten 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