{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:42:43Z","timestamp":1770842563480,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Beta\u2010trace protein (BTP), a low molecular weight protein of 23\u201029\u00a0kDa, has been proposed as a promising biomarker to estimate residual renal function (RRF) in patients on maintenance hemodialysis (HD). Indeed, BTP is cleared by native kidney but not during conventional HD session. By contrast, the removal rate of BTP using convective processes (mainly hemodiafiltration [HDF]) and peritoneal dialysis (PD) has been little or not investigated. Therefore, an aim of this study was to evaluate the impact of dialysis procedures (high\u2010flux HD, on\u2010line post\u2010dilution HDF and PD) on BTP removal in comparison with beta\u20102 microglobulin (B2M) and cystatin C (CYSC) removals after a single session. In addition, the ability of BTP to predict RRF in PD was assessed. This observational cross\u2010sectional study included a total of 82 stable chronic kidney disease patients, 53 patients were on maintenance dialysis (with n\u00a0=\u00a026 in HD and n\u00a0=\u00a027 in HDF) and 29 were on PD. Serum concentrations of BTP, B2M, and CYSC were measured (a) before and after a single dialysis session in HD and HDF anuric patients to calculate reduction percentages, (b) in serum, 24\u2010hour\u2010dialysate and 24\u2010hour\u2010urine in PD patients to compute total, peritoneal, and urinary clearance. RRF was estimated using four equations developed for dialysis patients without urine collection and compared to the mean of the urea and creatinine clearances in PD. The concentrations of the three studied molecules were significantly reduced (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) after dialysis session with significantly higher reduction ratio using HDF compared to HD modality (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001): BTP 49.3% vs 17.5%; B2M 82.3% vs 69.7%; CYSC 77.4% vs 66% in HDF and HD, respectively. In non\u2010anuric PD patients, B2M and CYSC were partly removed by peritoneal clearance (72.3% and 57.6% for B2M and CYSC, respectively). By contrast, BTP removal by the peritoneum was negligible and a low bias for the BTP\u2010based equation to estimate RRF (\u22121.4\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>) was calculated. BTP is significantly removed by high\u2010flux HD or HDF, thereby compromising its use to estimate RRF. By contrast, BTP appears as a promising biomarker to estimate RRF in PD patients since it is not affected by peritoneal clearance, unlike B2M and CYSC, and it is well correlated to RRF.<\/jats:p>","DOI":"10.1111\/aor.13641","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T12:50:11Z","timestamp":1579265411000},"page":"647-654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Estimation of residual renal function using beta\u2010trace protein: Impact of dialysis procedures"],"prefix":"10.1111","volume":"44","author":[{"given":"Anne\u2010Sophie","family":"Bargnoux","sequence":"first","affiliation":[{"name":"D\u00e9partement de Biochimie et Hormonologie PhyMedExp INSERM CNRS Universit\u00e9 de Montpellier CHU de Montpellier Montpellier Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Buthiau","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biochimie et Hormonologie Universit\u00e9 de Montpellier CHU de Montpellier Montpellier Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Morena","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biochimie et Hormonologie PhyMedExp INSERM CNRS Universit\u00e9 de Montpellier CHU de Montpellier Montpellier Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biochimie et Hormonologie Universit\u00e9 de Montpellier CHU de Montpellier Montpellier Cedex 5 France"},{"name":"AIDER Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u2010Eugenia","family":"Noguera\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie Dialyse et Transplantation CHU de Montpellier Universit\u00e9 de Montpellier Montpellier Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Gilbert","sequence":"additional","affiliation":[{"name":"AIDER Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moglie","family":"Le Quintrec","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie Dialyse et Transplantation CHU de Montpellier Universit\u00e9 de Montpellier Montpellier Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Kuster","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biochimie et Hormonologie PhyMedExp INSERM CNRS Universit\u00e9 de Montpellier CHU de Montpellier Montpellier Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-7278","authenticated-orcid":false,"given":"Jean\u2010Paul","family":"Cristol","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biochimie et Hormonologie PhyMedExp INSERM CNRS Universit\u00e9 de Montpellier CHU de Montpellier Montpellier Cedex 5 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000117976.29592.93"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00362-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12102158"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.09.001"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"S98","article-title":"Clinical practice guidelines for peritoneal dialysis adequacy","volume":"48","author":"Peritoneal Dialysis Adequacy Work Group","year":"2006","journal-title":"Am J Kidney Dis"},{"issue":"7","key":"e_1_2_9_7_1","first-page":"7","article-title":"Section I. 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