{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:10:27Z","timestamp":1771261827238,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61673271"],"award-info":[{"award-number":["61673271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601631"],"award-info":[{"award-number":["81601631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971767"],"award-info":[{"award-number":["81971767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While fecal incontinence (FI) is not fatal, it can dramatically decrease the patient\u2019s quality of life. An artificial anal sphincter (AAS) is an implantable device that treats FI by replacing a diseased or damaged anal sphincter, thus allowing the patient\u2019s continence to be maintained. Here, we report a novel implantable puborectalis\u2010like artificial anal sphincter (PAAS) that replicates rectal perception and has a low risk of ischemia necrosis. Using the pressure sensors embedded in the PAAS, the relationship between the mass of feces and the pressure was determined, and a feces mass estimation model was developed based on in\u00a0vitro studies. Rectal perception is provided through the real\u2010time monitoring of rectal feces, and the feeling of defecation is quantified based on a comparison between the feces mass and a preset threshold mass. In\u00a0vivo studies were performed for validation, and the accuracy of the model was determined to be as high as 90%. The performance of the PAAS in the real\u2010time monitoring of rectal feces and its in\u00a0vivo biocompatibility were also evaluated. The device should further the functionality of existing AAS systems while improving their biosafety and thus expand the applicability of implantable AAS systems in the treatment of FI.<\/jats:p>","DOI":"10.1111\/aor.13645","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T05:00:15Z","timestamp":1579755615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Design and evaluation of puborectalis\u2010like artificial anal sphincter that replicates rectal perception"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-0621","authenticated-orcid":false,"given":"Zerun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Instrument Science and Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guozheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Instrument Science and Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Instrument Science and Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Instrument Science and Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Instrument Science and Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengjian","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Instrument Science and Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zifan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Instrument Science and Engineering Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"National Institute for Health and Clinical Excellence (Great Britain).Faecal incontinence: the management of fecal incontinence in adults.Great Britain:National Institute for Health and clinical Excellence;2007. p.53\u20134"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.419"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-016-1572-z"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13164"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)39126-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12525"},{"issue":"2","key":"e_1_2_6_8_1","first-page":"149","article-title":"Long\u2010term outcomes of artificial bowel sphincter for fecal incontinence: a systematic review of gastrointestinal and liver diseases","volume":"24","author":"Hong 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