{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:38:20Z","timestamp":1791549500238,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cannula position in HeartMate II and HeartWare left ventricular assist devices (LVADs) is associated with clinical outcome. This study aimed to investigate the clinical implication of the device positioning in HeartMate 3 LVAD cohort. Consecutive patients who underwent HeartMate 3 LVAD implantation were followed for one year from index discharge. At index discharge, chest X\u2010ray parameters were measured: (a) cannula coronal angle, (b) height of pump bottom, (c) cannula sagittal angle, and (d) cannula lumen area. The association of each measurement of cannula position with one\u2010year clinical outcomes was investigated. Sixty\u2010four HeartMate 3 LVAD patients (58 years old, 64% male) were enrolled. In the multivariable Cox regression model, the cannula coronal angle was a significant predictor of death or heart failure readmission (hazard ratio 1.27 [1.01\u20101.60],\n                    <jats:italic>P<\/jats:italic>\n                    = .045). Patients with a cannula coronal angle \u226428\u00b0 had lower central venous pressure (\n                    <jats:italic>P<\/jats:italic>\n                    = .030), lower pulmonary capillary wedge pressure (\n                    <jats:italic>P<\/jats:italic>\n                    = .027), and smaller left ventricular size (\n                    <jats:italic>P<\/jats:italic>\n                    = .019) compared to those with the angle &gt;28\u00b0. Right ventricular size and parameters of right ventricular function were also better in the narrow angle group, as was one\u2010year cumulative incidence of death or heart failure readmission (10% vs. 50%,\n                    <jats:italic>P<\/jats:italic>\n                    = .008). Narrow cannula coronal angle in patients with HeartMate 3 LVADs was associated with improved cardiac unloading and lower incidence of death or heart failure readmission. Larger studies to confirm the implication of optimal device positioning are warranted.\n                  <\/jats:p>","DOI":"10.1111\/aor.13755","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T22:15:59Z","timestamp":1592518559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Optimal cannula positioning of HeartMate 3 left ventricular assist device"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-7637","authenticated-orcid":false,"given":"Teruhiko","family":"Imamura","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Chicago Medical Center Chicago IL USA"},{"name":"Second Department of Internal Medicine University of Toyama Toyama Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Narang","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Chicago Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Nitta","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Chicago Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Fujino","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Chicago Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Chicago Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Chicago Medical Center Chicago IL 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Sayer","sequence":"additional","affiliation":[{"name":"Division of Cardiology Columbia University Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Uriel","sequence":"additional","affiliation":[{"name":"Division of Cardiology Columbia University Medical Center New York NY 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