{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T09:41:36Z","timestamp":1786268496059,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In this proof of principle study, we investigated the effectiveness and safety of hemodynamic support with the Intra\u2010Ventricular Membrane Pump (IVMP). The IVMP was implanted into the apex of the left ventricle. Hemodynamic assessment was performed in six ex vivo beating porcine hearts (PhysioHeart platform). The cardiac output (CO), mean arterial pressure (MAP), coronary flow (CF) and pulse pressure (PP) were obtained before and during IVMP support and reported as means\u00a0\u00b1\u00a0standard deviations. In two additional visualization experiments, the integrity of the mitral valve was assessed during IVMP support. We found a significant increase of the CO (+1.4\u00a0\u00b1\u00a00.2 L\/min,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001), MAP (+13\u00a0\u00b1\u00a06\u00a0mm Hg,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.008), CF (+0.23\u00a0\u00b1\u00a00.1 L\/min,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.004), and PP (+15\u00a0\u00b1\u00a04\u00a0mm Hg,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.002) during IVMP support, when compared to baseline. No interference of the IVMP with mitral valve function was observed. An increase of premature ventricular complexes (PVC) was observed during support with the IVMP (mean PVC\u2010burden 4.3% vs. 0.7% at baseline), negatively influencing hemodynamic parameters. The IVMP is able to significantly improve hemodynamic parameters in a co\u2010pulsatile fashion, without hampering the function of the mitral valve. These findings provide a basis for future development of a catheter\u2010based IVMP.\n                  <\/jats:p>","DOI":"10.1111\/aor.13757","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T16:09:51Z","timestamp":1592496591000},"page":"1267-1275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Proof of principle of a novel co\u2010pulsating intra\u2010ventricular membrane pump"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1032-7491","authenticated-orcid":false,"given":"Dani\u00ebl I. M.","family":"van Dort","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Radboudumc Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8605-0436","authenticated-orcid":false,"given":"Jos","family":"Thannhauser","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboudumc Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-9868","authenticated-orcid":false,"given":"Frank D. H.","family":"Gommans","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboudumc Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Ten Cate","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboudumc Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-2241","authenticated-orcid":false,"given":"Dirk J.","family":"Duncker","sequence":"additional","affiliation":[{"name":"Department of Experimental Cardiology Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Suryapranata","sequence":"additional","affiliation":[{"name":"Department of Cardiology Radboudumc Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim J.","family":"Morshuis","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Radboudumc Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume S. 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