{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:31:10Z","timestamp":1790721070825,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003484","name":"Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf","doi-asserted-by":"publisher","award":["KS 9772519"],"award-info":[{"award-number":["KS 9772519"]}],"id":[{"id":"10.13039\/501100003484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Establishing a chronic heart failure (HF) model is challenging, particularly in the ovine model. The aim of this study was to establish a reproducible model of HF in an ovine model. Seventeen sheep were operated using the left thoracotomy approach. Chronic HF was induced through ligation of the diagonal and marginal branches only. Perioperative hemodynamic and echocardiographic parameters were compared. A total of (3\u00a0\u00b1\u00a01) coronary ligations were used. Thirteen animals survived the procedure and were followed up for (15\u00a0\u00b1\u00a05) days. The mean arterial pressure, heart rate (HR), mean pulmonary artery pressure (mPAP), central venous pressure, and cardiac output at baseline and prior to animal sacrifice was (75\u00a0\u00b1\u00a014\u00a0mmHg) and (68\u00a0\u00b1\u00a016\u00a0mmHg)\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.261; (72\u00a0\u00b1\u00a09 bpm), (100\u00a0\u00b1\u00a028 bpm)\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.01; (15\u00a0\u00b1\u00a04\u00a0mmHg) and (18\u00a0\u00b1\u00a05\u00a0mmHg)\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.034; (10\u00a0\u00b1\u00a06\u00a0mmHg) and (8\u00a0\u00b1\u00a04\u00a0mmHg)\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.326; (3.4\u00a0\u00b1\u00a01 L\/min) and (3.9\u00a0\u00b1\u00a01 L\/min)\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.286, respectively. The LVEF at baseline and prior to animal sacrifice was (63\u00a0\u00b1\u00a013%) and (43\u00a0\u00b1\u00a06%)\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.012. Twelve surviving animals were supported with LVAD in a follow\u2010up procedure. Chronic stable HF in sheep was successively established. Clinical symptoms and drastic increase in the mPAP and HR as well as echo findings were the most sensitive parameters of HF. This reproducible ovine model has proven to be highly promising for research regarding HF.\n                  <\/jats:p>","DOI":"10.1111\/aor.13772","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T19:04:03Z","timestamp":1594321443000},"page":"947-954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chronic stable heart failure model in ovine species"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5737-480X","authenticated-orcid":false,"given":"Carolin","family":"Torregroza","sequence":"first","affiliation":[{"name":"Department of Anesthesiology University Hospital Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najla","family":"Sadat","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery University Hospital Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio J. R.","family":"Gomez Hamacher","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery University Hospital Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Scheiber","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine Medical Faculty Heinrich\u2010Heine University Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jil\u2010Cathrin","family":"von der Beek","sequence":"additional","affiliation":[{"name":"Central Unit for Animal Research and Animal Welfare Affairs Heinrich Heine University Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Westenfeld","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine Medical Faculty Heinrich\u2010Heine University Duesseldorf 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7449-9455","authenticated-orcid":false,"given":"Diyar","family":"Saeed","sequence":"additional","affiliation":[{"name":"University Department for Cardiac Surgery Leipzig Heart Center Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.053"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"e_1_2_9_5_1","volume-title":"Gesundheit \u2010 Todesursachen in Deutschland 2015","author":"Deutschland 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