{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:06:05Z","timestamp":1785575165766,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Postinfarction ventricular septal defect (pVSD) due to acute myocardial infarction complicated by cardiogenic shock (CS) is associated with high mortality. The aim of this study was to determine the outcome of primary surgical repair of pVSD in patients with CS and examine whether it is influenced by the use of mechanical circulatory support (MCS) devices. Between October 1994 and April 2016, primary surgical repair of pVSD complicated by CS was performed in 53 patients. Thirty\u2010six (68%) were implanted pre\u2010operatively with an intra\u2010aortic balloon pump (IABP), 4 (8%) with extracorporeal life support (ECLS), and 13 (24%) received no MCS device. Prospectively collected demographic and perioperative data were analyzed retrospectively. All\u2010cause, 30\u2010day mortality rates were analyzed and multivariate analysis was performed to differentiate independent risk factors. No pre\u2010operatively implanted MCS device was able to improve 30\u2010day survival, whereas pre\u2010operatively implanted ECLS tended to have a positive effect (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.106). The post\u2010operative need for a MCS device or escalation of MCS invasiveness (IABP upgrade to ECLS) was associated with a higher 30\u2010day mortality (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) compared with patients without any MCS device or those with pre\u2010operatively implanted MCS devices. An independent risk factor for 30\u2010day mortality was the interval between acute myocardial infarction and surgery &lt;7\u00a0days (OR 5.895, CI 1.615\u201021.515; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007). Pre\u2010operative implantation of ECLS for CS tends to improve the outcome of early primary surgical pVSD repair. The need for a post\u2010operative MCS device is associated with a worse 30\u2010day survival after early primary surgical pVSD repair.<\/jats:p>","DOI":"10.1111\/aor.13808","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:01:03Z","timestamp":1598659263000},"page":"244-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Mechanical circulatory support for early surgical repair of postinfarction ventricular septal defect with cardiogenic shock"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5734-6668","authenticated-orcid":false,"given":"Maximilian","family":"Vondran","sequence":"first","affiliation":[{"name":"University Department for Cardiac Surgery Heart Center Leipzig Leipzig Germany"},{"name":"Department of Cardiac and Vascular Thoracic Surgery Philipps\u2010University Hospital Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud S.","family":"Wehbe","sequence":"additional","affiliation":[{"name":"University Department for Cardiac Surgery Heart Center Leipzig Leipzig Germany"},{"name":"Department of Cardiac Surgery Sana Herzchirurgie Stuttgart Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Etz","sequence":"additional","affiliation":[{"name":"University Department for Cardiac Surgery Heart Center Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Ghazy","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Thoracic Surgery Philipps\u2010University Hospital Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardawan J.","family":"Rastan","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Thoracic Surgery Philipps\u2010University Hospital Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Borger","sequence":"additional","affiliation":[{"name":"University Department for Cardiac Surgery Heart Center Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schroeter","sequence":"additional","affiliation":[{"name":"University Department for Cardiac Surgery Heart Center Leipzig Leipzig 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