{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:56:22Z","timestamp":1784001382842,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Continuous flow left ventricular assist devices (LVADs) have become a valuable therapy for end\u2010stage heart failure. In vitro research highlighted a role of outflow cannula position on the pattern of blood flow in the aorta. However, the clinical effects of the alterations of flow remain unclear. We investigate short\u2010 and long\u2010term outcomes of patients implanted with Jarvik 2000 LVAD, according to the ascending (Group 1) versus descending (Group 2) outflow graft connection to the aorta in a multicenter study. From May 2008 to October 2014, 140 consecutive end\u2010stage heart failure patients underwent Jarvik 2000 LVAD implantation in 17 Italian centers. According with a preliminary multivariate analysis, we selected the 90 patients implanted in the four high\u2010volume centers to avoid bias (Group 1 n\u00a0=\u00a039, Group 2 n\u00a0=\u00a051). Among the groups, no differences were recorded in the hospital mortality and the main complications occurring after LVAD implantation were similar. In multivariable analysis, the ascending aorta outflow cannula position and higher creatinine at discharge were significant predictors for long\u2010term survival. Postimplant hemolysis was more pronounced in descending aorta outflow graft anastomosis. Outflow graft anastomosis to the ascending aorta is associated with better long\u2010term survival, independent of age and perfusion techniques, reflecting the previous in vitro results.<\/jats:p>","DOI":"10.1111\/aor.13809","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T08:38:54Z","timestamp":1598690334000},"page":"236-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["From bench to bedside: Impact of left ventricular assist device outflow conduit anastomosis position on outcome"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2360-2031","authenticated-orcid":false,"given":"Vincenzo","family":"Tarzia","sequence":"first","affiliation":[{"name":"Cardiac Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padova Padova 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