{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:23:49Z","timestamp":1791894229747,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prolonged cardiac arrest (CA) may lead to neurologic deficit in survivors. Good outcome is especially rare when CA was unwitnessed. However, accidental hypothermia is a very specific cause of CA. Our goal was to describe the outcomes of patients who suffered from unwitnessed hypothermic cardiac arrest (UHCA) supported with Extracorporeal Life Support (ECLS). We included consecutive patients\u2019 cohorts identified by systematic literature review concerning patients suffering from UHCA and rewarmed with ECLS. Patients were divided into four subgroups regarding the mechanism of cooling, namely: air exposure; immersion; submersion; and avalanche. A statistical analysis was performed in order to identify the clinical parameters associated with good outcome (survival and absence of neurologic impairment). A total of 221 patients were included into the study. The overall survival rate was 27%. Most of the survivors (83%), had no neurologic deficit. Asystole was the presenting CA rhythm in 48% survivors, of which 79% survived with good neurologic outcome. Variables associated with survival included the following: female gender (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001); low core temperature (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.005); non\u2010asphyxia\u2010related mechanism of cooling (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001); pulseless electrical activity as an initial rhythm (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001); high blood pH (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001); low lactate levels (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.003); low serum potassium concentration (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001); and short resuscitation duration (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.004). Severely hypothermic patients with unwitnessed CA may survive with good neurologic outcome, including those presenting as asystole. The initial blood pH, potassium, and lactate concentration may help predict outcome in hypothermic CA.\n                  <\/jats:p>","DOI":"10.1111\/aor.13818","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T16:19:31Z","timestamp":1601309971000},"page":"222-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Outcomes of patients suffering unwitnessed hypothermic cardiac arrest rewarmed with extracorporeal life support: A systematic review"],"prefix":"10.1111","volume":"45","author":[{"given":"Pawe\u0142","family":"Podsiad\u0142o","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Jan Kochanowski University Kielce Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5889-3209","authenticated-orcid":false,"given":"Tomasz","family":"Darocha","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind S.","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylweriusz","family":"Kosi\u0144ski","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Silfvast","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care and Pain Medicine University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Blancher","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine SAMU 38 University Hospital of Grenoble Alps Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Sawamoto","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Sapporo Medical University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Pasquier","sequence":"additional","affiliation":[{"name":"Emergency Department Lausanne University Hospital Lausanne 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