{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:31:50Z","timestamp":1771468310179,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In donation after circulatory death heart transplantation, the donor heart is exposed to circulatory load. The right ventricle, due to its structure, has high compliance for volume load but is particularly vulnerable to increased pressure load. This study used a porcine model to conduct a functional assessment of the hemodynamics of the heart, with a focus on the right ventricle. Six pigs weighing 24.6\u00a0\u00b1\u00a01.4\u00a0kg were used. Circulatory death was induced by asphyxiation after median sternotomy. After 30\u00a0minutes in the state of global warm ischemia, the ascending aorta was clamped, followed by a 20\u2010minute reperfusion of the heart with a 20\u00b0C blood cardioplegia solution. Systemic circulation was established by cardiopulmonary bypass after aortic cross\u2010clamping. After initial reperfusion, the blood cardioplegia solution was replaced with blood. The blood was then rewarmed while the heart was still in a non\u2010working state. Cardiac function was assessed twice in situ, first by the thermodilution method, and then, by the pressure\u2013volume measurement both at preischemia and at three hours after initiation of reperfusion. The recovery rate of cardiac output was 75%. End\u2010systolic elastance (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) and pulmonary arterial elastance significantly increased (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03), but the ratio of arterial elastance to end\u2010systolic elastance was preserved (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.91) in the right ventricle. Despite a decrease in cardiac output after reperfusion from warm ischemia, the right ventricle had a potential to respond the elevated afterload. It is important that donations after circulatory death heart transplantation should be performed with attention to avoiding right ventricular distension.<\/jats:p>","DOI":"10.1111\/aor.13823","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T22:15:53Z","timestamp":1601158553000},"page":"263-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of the right ventricle in donation after circulatory death hearts"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5563-7450","authenticated-orcid":false,"given":"Sachiko","family":"Kadowaki","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Okayama University Okayama 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