{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:29:39Z","timestamp":1773149379875,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the benefit of left ventricular (LV) unloading using a percutaneous transseptal left atrial (LA) drain catheter via femoral vein incorporated into the ECMO venous circuit. This single\u2010center retrospective observational study analyzed clinical outcomes of the LA venting group (N\u00a0=\u00a062) who underwent percutaneous transseptal LA drain placement comparing with the conventionally treated control group (N\u00a0=\u00a062) with an arterial pulse pressure below 10\u00a0mm Hg for at least 24\u00a0hours from December 2012 to August 2018. The ECMO weaning rate (61.3% vs. 38.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.012) and cardiac transplantation rate (29.0% vs. 11.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.014) were higher in the LA venting group than in the control group. Inhospital mortality was not significantly different (56.5% vs. 69.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.191). Pulmonary congestion mostly improved after LA decompression (61.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003). A serum lactate level at 24\u00a0hours after LA venting of more than 2.2\u00a0mmol\/L was associated with poor outcomes. LA venting via transseptal cannula reduced pulmonary venous congestion and achieved higher rates of successful ECMO weaning and cardiac transplantation. Placement of a transseptal venous drain cannula should be considered in patients with uncontrolled pulmonary edema secondary to severe LV loading undergoing VA\u2010ECMO.<\/jats:p>","DOI":"10.1111\/aor.13838","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T17:08:31Z","timestamp":1601572111000},"page":"390-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Outcomes of left ventricular unloading with a transseptal cannula during extracorporeal membrane oxygenation in adults"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-948X","authenticated-orcid":false,"given":"Ah\u2010Ram","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul 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