{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:45:35Z","timestamp":1770979535415,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extracorporeal cardiopulmonary resuscitation (eCPR) is a rapidly growing treatment strategy due to significant improvement in selected patients' survival rates. Gender\u2010related differences might impact the outcome of therapeutic measures. Therefore, we sought to investigate patients with eCPR at our interdisciplinary extracorporeal membrane oxygenation center regarding sex\u2010related differences with the view to potentially adjusting current selection criteria. From January 2016 to December 2019, 71 patients underwent eCPR at our institution. Data before eCPR and early outcome parameters were analyzed comparing male and female patients. The cohort analyzed consisted of 60 male (84%) and 11 female (15%) patients. Comparing both groups, male patients significantly more frequently suffered out\u2010of\u2010hospital cardiac arrest (68% male vs. 36% female, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04), whereas female patients were associated with more in\u2010hospital cardiac arrest (32% male vs. 64% female, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). Creatinine levels differed significantly (1.5 (1.1;2.1) mg\/dL in male vs. 1.0 (0.7;1.5) mg\/dL in female patients, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). Also, several hepatic parameters showed a significant difference between the groups: aspartate aminotransferase 423 (249;804) U\/L in male vs. 115 (61;408) U\/L in female patients, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01; alanine aminotransferase 174 (102;446) U\/L in male vs. 86 (36;118) U\/L in female patients, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Renal failure requiring hemodialysis occurred more frequently in men than in women (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). There is a significant effect of male sex regarding renal failure with subsequent continuous venovenous hemodialysis (CVVH) (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.11, ANOVA <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01, 95% CI\u00a0=\u00a0\u22120.79\u2010\u22120.079). However, in\u2010hospital mortality was comparable between the groups (78% in male vs. 72% in female patients, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.68). Our retrospective study showed several gender\u2010related differences associated with different cardiac arrest scenarios. Male sex was associated with a significantly higher risk for renal failure requiring CVVH. Survival rates were comparable between the groups. Further investigations should include gender in the evaluation of risk stratification for eCPR\u2010related complications to further improve selection criteria for this demanding therapy.<\/jats:p>","DOI":"10.1111\/aor.13844","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T18:31:17Z","timestamp":1602700277000},"page":"488-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Gender\u2010related differences in treatment and outcome of extracorporeal cardiopulmonary resuscitation\u2010patients"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7232-3330","authenticated-orcid":false,"given":"Christopher","family":"Gaisendrees","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne Cologne 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