{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:04:31Z","timestamp":1790777071989,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM19\/00055"],"award-info":[{"award-number":["CM19\/00055"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Weaning failure and mortality rates in veno\u2010arterial extracorporeal membrane oxygenation (VA\u2010ECMO) supported patients are significant. Small studies suggest the possible usefulness of levosimendan in this environment, especially in postcardiotomy shock. We performed a retrospective analysis of VA\u2010ECMO implants in a referral hospital comparing weaning failure and survival of patients treated with levosimendan with a control group. From 2013 to May 2020, 123 VA\u2010ECMO for several indications were implanted. Levosimendan was administered in 23 patients (18.7%) with good tolerance. Levosimendan was used more frequently in cardiogenic shock due to acute coronary syndrome indication, and in patients with lower left ventricular ejection fraction (LVEF) at the implant. No significant differences were found in success of ECMO weaning (60.9% levosimendan group vs. 44% non\u2010levosimendan group, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.169) despite worse LVEF in levosimendan group. Survival at follow\u2010up (20.6 [58] months) was higher in the group that received levosimendan, although without finding statistically significant differences (47.8% vs. 32.0%, log rank <jats:italic>P<\/jats:italic>\u00a0=\u00a0.124). Levosimendan can be safely administered during VA\u2010ECMO support. Patients receiving levosimendan were weaned similarly from circulatory support despite worse LVEF. Its use did not influence in short\u2010 and medium\u2010term survival. Randomized studies are needed to evaluate the levosimendan impact in this indication.<\/jats:p>","DOI":"10.1111\/aor.13899","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T12:58:16Z","timestamp":1609333096000},"page":"717-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Levosimendan in veno\u2010arterial extracorporeal membrane oxygenator supported patients: Impact on the success of weaning and survival"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4363-8835","authenticated-orcid":false,"given":"Marta","family":"Alonso\u2010Fernandez\u2010Gatta","sequence":"first","affiliation":[{"name":"Cardiology Department University Hospital of Salamanca \u2013 IBSAL, CIBER\u2010CV Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Merchan\u2010Gomez","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital of Salamanca \u2013 IBSAL, CIBER\u2010CV Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miryam","family":"Gonzalez\u2010Cebrian","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital of Salamanca \u2013 IBSAL, CIBER\u2010CV Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Diego\u2010Nieto","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital of Salamanca \u2013 IBSAL, CIBER\u2010CV Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabete","family":"Alzola","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital of Salamanca \u2013 IBSAL, CIBER\u2010CV Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Toranzo\u2010Nieto","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital of Salamanca \u2013 IBSAL, CIBER\u2010CV Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Barrio","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital of Salamanca \u2013 IBSAL, CIBER\u2010CV Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Martin\u2010Herrero","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital of Salamanca \u2013 IBSAL, CIBER\u2010CV Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital of Salamanca \u2013 IBSAL, CIBER\u2010CV Salamanca 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