{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:35:14Z","timestamp":1771266914619,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Activation of the complement system and leukocytes by blood\u2013membrane interactions may further promote arteriosclerosis typically present in patients on lipoprotein apheresis. As clinical data on the hemocompatibility of lipoprotein apheresis are scarce, a controlled clinical study comparing two different types of plasma separation and fractionation membranes used in double\u2010filtration lipoprotein apheresis was urgently needed, as its outcome may influence clinical decision\u2010making. In a prospective, randomized, crossover controlled trial, eight patients on double\u2010filtration lipoprotein apheresis were subjected to one treatment with recent polyethersulfone (PES) plasma separation and fractionation membranes and one control treatment using a set of ethylene\u2010vinyl alcohol copolymer (EVAL) membranes. White blood cell (WBC) and platelet (PC) counts, complement factor C5a and thrombin\u2013antithrombin III (TAT) concentrations were determined in samples drawn at defined times from different sites of the extracorporeal blood and plasma circuit. With a nadir at 25\u00a0minutes, WBCs in EVAL decreased to 33.5\u00a0\u00b1\u00a010.7% of baseline compared with 63.8\u00a0\u00b1\u00a022.0% at 20\u00a0minutes in PES (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The maximum C5a levels in venous blood reentering the patients were measured at 30\u00a0minutes, being 30.0\u00a0\u00b1\u00a011.2\u00a0\u00b5g\/L with EVAL and 12.3\u00a0\u00b1\u00a09.0\u00a0\u00b5g\/L with PES (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The highest C5a concentrations were found in plasma after the plasma filters (EVAL 56.1\u00a0\u00b1\u00a022.0\u00a0\u00b5g\/L at 15\u00a0minutes vs PES 23.3\u00a0\u00b1\u00a015.2\u00a0\u00b5g\/L at 10\u00a0minutes; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). PC did not significantly decrease over time with both membrane types, whereas TAT levels did not rise until the end of the treatment without differences between membranes. Regarding lipoprotein(a) and low\u2010density lipoprotein (LDL) cholesterol removal, both membrane sets performed equally. Compared with EVAL, PES membranes cause less leukocyte and complement system activation, the classical parameters of hemocompatibility of extracorporeal treatment procedures, at identical treatment efficacy. Better hemocompatibility may avoid inflammation\u2010promoting effects through blood\u2013material interactions in patients requiring double\u2010filtration lipoprotein apheresis.<\/jats:p>","DOI":"10.1111\/aor.13944","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T19:44:56Z","timestamp":1614023096000},"page":"1104-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical hemocompatibility of double\u2010filtration lipoprotein apheresis comparing polyethersulfone and ethylene\u2010vinyl alcohol copolymer membranes"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9173-4859","authenticated-orcid":false,"given":"Detlef H.","family":"Krieter","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Medicine I University Hospital W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarline","family":"Jeyaseelan","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine I University Hospital W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke","family":"R\u00fcth","sequence":"additional","affiliation":[{"name":"eXcorLab GmbH Obernburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst\u2010Dieter","family":"Lemke","sequence":"additional","affiliation":[{"name":"eXcorLab GmbH Obernburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Wanner","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine I University Hospital W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Drechsler","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine I University Hospital W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197704072961401"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.36"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101755.1999.00784.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/362801a0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.07.012"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1456"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002432"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.02.017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2016.09.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V13suppl_1s62"},{"key":"e_1_2_8_12_1","first-page":"M144","article-title":"Evaluation of materials for use in extracorporeal circulation. 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