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In many cases, the TandemHeart system is used to unload the left heart by draining blood from the left atrium (LA) to the femoral artery via a transseptal multistage cannula. However, even though the correct positioning of the cannula is crucial for a safe treatment, the long cannula tip currently used in transseptal cannulas complicates positioning, making the cannula vulnerable to displacement during MCS. To overcome these limitations, we propose the development of a new tipless transseptal cannula with improved hemodynamic properties. We discuss the tipless cannula concept by comparing it to the common multistage cannula concept using computational fluid dynamics simulations and assess the flow field in the LA, the wall shear stresses (WSS), and the pressure loss. Across the two distinct time points of end\u2010systole and end\u2010diastole and two drainage flow rates of 3.5 and 5.0\u00a0L\/min, we find a more homogeneous inlet flow pattern for the tipless cannula concept, accompanied by a remarkably reduced area of platelet\u2010activating WSS (up to 10\u2010times smaller area compared to the multistage cannula). Moreover, pressure loss is up to 14.5% lower in the tipless cannula concept, confirming overall improved hemodynamic properties of the tipless cannula concept. Finally, a diameter\u2010dependent study reveals that lower WSS and pressure losses can be further reduced by large\u2010lumen designs for any simulation setting. Overall, our results suggest that a tipless cannula concept remedies the crucial disadvantages of a long\u2010tip multistage cannula by reducing the risk of misplacement, and it furthermore promotes optimized hemodynamics. With this successful proof\u2010of\u2010concept, we underscore the potential for and encourage the realization of further experimental investigations regarding the development of a tipless transseptal cannula for MCS.<\/jats:p>","DOI":"10.1111\/aor.13964","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T09:54:24Z","timestamp":1618394064000},"page":"1024-1035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tipless transseptal cannula concept combines improved hemodynamic properties and risk\u2010reduced placement: An in silico proof\u2010of\u2010concept"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6672-4990","authenticated-orcid":false,"given":"Kristin","family":"Hugenroth","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Engineering Institute of Applied Medical Engineering Faculty of Medicine RWTH Aachen University Aachen Germany"},{"name":"enmodes GmbH Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Neidlin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Engineering Institute of Applied Medical Engineering Faculty of Medicine RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich M.","family":"Engelmann","sequence":"additional","affiliation":[{"name":"enmodes GmbH Aachen Germany"},{"name":"Department of Medical Engineering and Applied Mathematics FH Aachen University of Applied Sciences Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim A. 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