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Hemoadsorption with CytoSorb is a novel approach to limit the inflammatory response, and the device can be safely and easily installed into ECMO circuits. CytoSorb has been used more than 130.000 times to date, but because randomized controlled trials are largely lacking, there is substantial debate on its use. Here, experts from critical care medicine, cardiology, cardiac surgery, and perfusion technology discuss the pros and cons of this novel therapy and outline the future aspects for its clinical application and research.<\/jats:p>","DOI":"10.1111\/aor.14025","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T12:59:40Z","timestamp":1624280380000},"page":"1240-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Opportunities, controversies, and challenges of extracorporeal hemoadsorption with CytoSorb during ECMO"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-0842","authenticated-orcid":false,"given":"L. 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