{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:44:13Z","timestamp":1783028653030,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2018\/02\/X\/NZ5\/02693"],"award-info":[{"award-number":["2018\/02\/X\/NZ5\/02693"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe accidental hypothermia carries high mortality and morbidity and is often treated with invasive extracorporeal methods. Continuous veno\u2010venous hemodiafiltration (CVVHDF) is widely available in intensive care units. We sought to provide theoretical basis for CVVHDF use in rewarming of hypothermic patients. CVVHDF system was used in the laboratory setting. Heat balance and transferred heat units were evaluated for the system without using blood. We used 5L of crystalloid solution at the temperature of approximately 25\u00b0C, placed in a thermally insulated tank (representing the \u201ccentral compartment\u201d of a hypothermic patient). Time of warming the central compartment from 24.9 to 30.0\u00b0C was assessed with different flow combinations: \u201cblood\u201d (central compartment fluid) 50 or 100 or 150\u00a0mL\/min, dialysate solution 100 or 1500\u00a0mL\/h, and substitution fluid 0 or 500\u00a0mL\/h. The total circulation time was 1535\u00a0minutes. There were no differences between heat gain values on the filter depending on blood flow (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.53) or dialysate flow (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.2). The mean heating time for \u201cblood\u201d flow rates 50, 100, and 150\u00a0mL\/min was 113.7\u00a0minutes (95% CI, 104.9\u2010122.6\u00a0minutes), 83.3\u00a0minutes (95% CI, 76.2\u201090.3\u00a0minutes), and 74.7\u00a0minutes (95% CI, 62.6\u201086.9\u00a0minutes), respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). The respective median rewarming rate for different \u201cblood\u201d flows was 3.6\u00b0C\/h (IQR, 3.0\u20104.2\u00b0C\/h), 4.8 (IQR, 4.2\u20105.4\u00b0C\/h), and 5.4 (IQR, 4.8\u20106.0\u00b0C\/h), respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). The dialysate flow did not affect the warming rate. Based on our experimental model, CVVHDF may be used for extracorporeal rewarming, with the rewarming rates increasing achieved with higher blood flow rates.<\/jats:p>","DOI":"10.1111\/aor.14032","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T03:39:30Z","timestamp":1625456370000},"page":"1360-1367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The efficiency of continuous renal replacement therapy for rewarming of patients in accidental hypothermia\u2013\u2013An experimental study"],"prefix":"10.1111","volume":"45","author":[{"given":"Konrad","family":"Mendrala","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylweriusz","family":"Kosi\u0144ski","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences 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Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Paal","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Hospitaller Brothers Hospital Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Gajniak","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5889-3209","authenticated-orcid":false,"given":"Tomasz","family":"Darocha","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medical University of Silesia Katowice 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