{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:40:06Z","timestamp":1747183206190,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coagulopathy is common during left ventricular assist device (LVAD) implantation, treatment of which can be challenging given the often\u2010limited ability for the right ventricle to accommodate volume transfusion after device initiation with 20% to 40% of patients developing right ventricular failure (RVF). Transfusion of plasma late on cardiopulmonary bypass (CPB) combined with ultrafiltration may replace clotting factors while reducing volume administration. We compared outcomes in patients undergoing LVAD implantation receiving plasma on CPB and ultrafiltration with traditional transfusion practices. Co\u2010primary outcomes needed for blood product transfusion in the first 6 and 24\u00a0hours after CPB. Secondary outcomes included metrics of morbidity and mortality. 396 patients were analyzed (59 plasma on CPB). Patients receiving plasma on CPB had a greater volume of blood products transfused (3764 vs. 2741\u00a0mL first 6\u00a0hours; 6059 vs. 4305\u00a0mL first 24\u00a0hours) in unadjusted analysis. In adjusted analysis, plasma transfusion on CPB with ultrafiltration had no significant effect on the primary outcomes of blood products given in the first 6\u00a0hours (estimated effect size 982 [\u2212428, 2392] mL, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.17) and 24\u00a0hours (estimated effect size 1076 [\u2212904, 3057] mL, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.29). Patients receiving plasma on CPB were more likely on either vasopressors or inotropes at 24\u00a0hours after ICU admission (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), however, indices of coagulopathy and RVF were similar between groups. While prospective studies would be necessary to definitively evaluate the clinical utility of this strategy, no signal for benefit was observed suggesting plasma should not be used for this purpose.<\/jats:p>","DOI":"10.1111\/aor.14052","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T15:21:53Z","timestamp":1629213713000},"page":"491-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of plasma late on cardiopulmonary bypass in patients undergoing left ventricular assist device implantation"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-2543","authenticated-orcid":false,"given":"James A.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Diaz Soto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Warner","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Stulak","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip J.","family":"Schulte","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Weister","sequence":"additional","affiliation":[{"name":"Anesthesia Information and Management Analytics \u2013 Anesthesia Clinical Research Unit Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Mauermann","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-4335","authenticated-orcid":false,"given":"Mark M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Mayo Clinic  Rochester MN 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