{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:47:13Z","timestamp":1758818833501,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although depressive symptoms are associated with an increased risk of readmission after left ventricular assist device (LVAD) implantation, it is unclear whether they affect the efficacy of exercise\u2010based cardiac rehabilitation (EBCR). This study aimed to investigate the effect of depressive symptoms on EBCR efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 48 patients who participated in EBCR after LVAD implantation (mean age 45\u00a0\u00b1\u00a012\u00a0years; 60% male). Patients were classified into two groups using the Zung Self\u2010Rating Depression Scale (SDS): depressive group (SDS \u226540, <jats:italic>n<\/jats:italic>\u00a0=\u00a027) and non\u2010depressive group (SDS &lt;40, <jats:italic>n<\/jats:italic>\u00a0=\u00a021). We examined changes in peak oxygen uptake (VO<jats:sub>2<\/jats:sub>), knee extensor muscular strength (KEMS), and quality of life (QOL) during EBCR using analysis of covariance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although baseline characteristics were similar between the two groups, the non\u2010depressive group was less likely to receive diuretics (22% vs. 52%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.030). Peak VO<jats:sub>2<\/jats:sub>, KEMS, and QOL significantly increased over time in both groups (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The depressive group had a significantly lower change in peak VO<jats:sub>2<\/jats:sub> than the non\u2010depressive group (2.7 vs. 1.6\u00a0ml\/kg\/min; mean difference: \u22121.1\u00a0ml\/kg\/min, 95% confidence interval [CI]: \u22120.045 to \u22122.17; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.041, <jats:italic>d<\/jats:italic>\u00a0=\u00a00.59). There was no between\u2010group difference regarding the change in KEMS or QOL. Adjusting for the baseline value, a significant difference between groups was observed only in peak VO<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.045).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although EBCR significantly improved exercise capacity after LVAD implantation, depressive symptoms interfered with this improvement. Further studies are needed to determine whether psychological interventions for depression, in addition to EBCR, would improve the response to EBCR after LVAD implantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14072","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T02:39:34Z","timestamp":1631673574000},"page":"471-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Depressive symptoms interfere with the improvement in exercise capacity by cardiac rehabilitation after left ventricular assist device implantation"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1955-257X","authenticated-orcid":false,"given":"Kazufumi","family":"Kitagaki","sequence":"first","affiliation":[{"name":"Faculty of Rehabilitation Shijonawate Gakuen University  Osaka Japan"},{"name":"Department of Public Health Kobe University Graduate School of Health Sciences  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Public Health Kobe University Graduate School of Health Sciences  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Rehabilitation National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Rehabilitation National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Nursing National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-0722","authenticated-orcid":false,"given":"Michio","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Rehabilitation National Cerebral and Cardiovascular Center  Osaka Japan"},{"name":"Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.779"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000757"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.12.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001391"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.11.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12172"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2016.01.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-0976"},{"key":"e_1_2_10_10_1","first-page":"327","article-title":"Depression and heart failure: an overview of what we know and don\u2019t know","volume":"18","author":"Marc AS","year":"2006","journal-title":"Int Psychogeriatr"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.117390"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.05.015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.01.1222"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.08.012"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487314558772"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.02.021"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.06.011"},{"issue":"12","key":"e_1_2_10_18_1","first-page":"I198","article-title":"Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients","volume":"106","author":"Ochiai Y","year":"2002","journal-title":"Circulation"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.071"},{"key":"e_1_2_10_20_1","first-page":"38","article-title":"CONUT: a tool for controlling nutritional status. First validation in a hospital population","volume":"20","author":"Ignacio de Ul\u00edbarri J","year":"2005","journal-title":"Nutr Hosp"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01730060026004"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.53.146"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(97)90005-8"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00095-X"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.017"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012175"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7321.1123"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000736"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12362"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487316667781"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474515116666475"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319832393"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13351"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.14072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T15:16:43Z","timestamp":1692976603000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.14072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,26]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/aor.14072"],"URL":"https:\/\/doi.org\/10.1111\/aor.14072","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"type":"print","value":"0160-564X"},{"type":"electronic","value":"1525-1594"}],"subject":[],"published":{"date-parts":[[2021,9,26]]},"assertion":[{"value":"2021-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}