{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:16:11Z","timestamp":1777104971246,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of left ventricular assist devices (LVAD) in patients with advance heart failure is still associated with an important risk of immune dysregulation and infections. The aim of this study was to determine whether extracorporeal blood purification using the CytoSorb device benefits patients after LVAD implantation in terms of complications and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Between August 2010 and January 2020, 207 consecutive patients underwent LVAD implantation, of whom 72 underwent CytoSorb therapy and 135 did not. Overall survival, major adverse events, and laboratory parameters were compared between 112 propensity score\u2010matched patients (CytoSorb: 72 patients; non\u2010CytoSorb: 40 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>WBC (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.033), CRP (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), and IL\u20106 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), significantly increased with LVAD implantation, while CytoSorb did not influence this response. In\u2010hospital mortality and overall survival during follow\u2010up were similar with CytoSorb. However, patients treated with CytoSorb were more likely to develop respiratory failure (54.2% vs. 30.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.024), need mechanical ventilation for longer than 6\u00a0days post\u2010implant (50.0% vs. 27.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.035), and require tracheostomy during hospitalization (31.9% vs. 12.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.040). No other significant differences were observed with regard to major adverse events during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, our results showed that CytoSorb might not convey a significant morbidity or mortality benefit for patients undergoing LVAD implantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.14099","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T14:22:31Z","timestamp":1635171751000},"page":"95-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Initial experience with CytoSorb therapy in patients receiving left ventricular assist devices"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-3736","authenticated-orcid":false,"given":"Konstantin","family":"Zhigalov","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery West German Heart and Vascular Center Essen University Hospital of Essen University Duisburg\u2010Essen  Essen Germany"},{"name":"International Thoracic and Cardiovascular Research Association (ITCVR)  Oldenburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-376X","authenticated-orcid":false,"given":"Jef","family":"Van den Eynde","sequence":"additional","affiliation":[{"name":"International Thoracic and Cardiovascular Research Association (ITCVR)  Oldenburg Germany"},{"name":"Department of Cardiovascular Sciences Unit of Cardiac Surgery University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2444-5747","authenticated-orcid":false,"given":"Alina","family":"Zubarevich","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery West German Heart and Vascular Center Essen University Hospital of Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Chrosch","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery West German Heart and Vascular Center Essen University Hospital of Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Goerdt","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery West German Heart and Vascular Center Essen University Hospital of Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-4049","authenticated-orcid":false,"given":"Arian","family":"Arjomandi Rad","sequence":"additional","affiliation":[{"name":"International Thoracic and Cardiovascular Research Association (ITCVR)  Oldenburg Germany"},{"name":"Department of Medicine Faculty of Medicine Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Vardanyan","sequence":"additional","affiliation":[{"name":"International Thoracic and Cardiovascular Research Association (ITCVR)  Oldenburg Germany"},{"name":"Department of Medicine Faculty of Medicine Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel Pompeu Barros Oliveira","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"International Thoracic and Cardiovascular Research Association (ITCVR)  Oldenburg Germany"},{"name":"Department of Cardiovascular Surgery Pronto Socorro Cardiol\u00f3gico de Pernambuco (PROCAPE)  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Luedike","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine West German Heart and Vascular Center Essen University Hospital of Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Pizanis","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery West German Heart and Vascular Center Essen University Hospital of Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery West German Heart and Vascular Center Essen University Hospital of Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastian","family":"Schmack","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery West German Heart and Vascular Center Essen University Hospital of Essen University Duisburg\u2010Essen  Essen 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