{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:45:14Z","timestamp":1786157114035,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010pulsatile cardiopulmonary bypass (CPB) may induce microvascular dysregulation. In piglets, we compared ocular surface microcirculation during pulsatile versus continuous flow (CF) bypass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ocular surface microcirculation in small tissue volumes (~0.1 mm\n                      <jats:sup>3<\/jats:sup>\n                      ) at limbus (high metabolic rate) and bulbar conjunctiva (low metabolic rate) was examined in a porcine model using computer assisted video microscopy and diffuse reflectance spectroscopy, before and after 3 and 6\u00a0h of pulsatile (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05 piglets) or CF (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03 piglets) CPB. Functional capillary density, capillary flow velocity and microvascular oxygen saturation were quantified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At limbus, velocities improved with pulsatility (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01) and deteriorated with CF (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). In bulbar conjunctiva, velocities were severely reduced with CF (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), accompanied by an increase in capillary density (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). Microvascular oxygen saturation decreased in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ocular surface capillary densities and flow patterns are better preserved with pulsatile versus CF during 6\u00a0h of CPB in sleeping piglets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14137","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T03:21:45Z","timestamp":1638760905000},"page":"786-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ocular surface microcirculation is better preserved with pulsatile versus continuous flow during cardiopulmonary bypass\u2014An experimental pilot"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9345-1876","authenticated-orcid":false,"given":"Anne Kari","family":"Kvernebo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"The Circulation Laboratory, Department of Cardiothoracic Surgery Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-8825","authenticated-orcid":false,"given":"Takuma","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Cleveland Clinic Lerner Research Institute  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-9490","authenticated-orcid":false,"given":"Liv","family":"Drolsum","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2318-2017","authenticated-orcid":false,"given":"Morten Carstens","family":"Moe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svein\u2010Erik","family":"M\u00e5s\u00f8y","sequence":"additional","affiliation":[{"name":"ODI Medical AS  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengo","family":"Sunagawa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Cleveland Clinic Lerner Research Institute  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Dessoffy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Cleveland Clinic Lerner Research Institute  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-0415","authenticated-orcid":false,"given":"Jamshid H.","family":"Karimov","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Cleveland Clinic Lerner Research Institute  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4852-8416","authenticated-orcid":false,"given":"Kiyotaka","family":"Fukamachi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Cleveland Clinic Lerner Research Institute  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-5829","authenticated-orcid":false,"given":"Knut","family":"Kvernebo","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"The Circulation Laboratory, Department of Cardiothoracic Surgery Oslo University Hospital  Oslo Norway"},{"name":"ODI Medical AS  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.08.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)01329-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1441-2772(23)01792-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.09.012"},{"issue":"42","key":"e_1_2_8_6_1","first-page":"M724","article-title":"The role of pulsatility in end\u2010organ microcirculation after cardiogenic shock","volume":"1996","author":"Orime Y","year":"1992","journal-title":"ASAIO J"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.1999.06318.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20170033"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-200895"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2011.02.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.16"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-131764"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108312"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12389"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-131670"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2010.00994.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.139"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12604"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005201"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14119"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12875"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.01.007"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2002.07127.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2011.01378.x"},{"issue":"50","key":"e_1_2_8_25_1","first-page":"321","article-title":"Microcirculation of the bulbar conjunctiva in the goat implanted with a total artificial heart: effects of pulsatile and nonpulsatile flow","volume":"2004","author":"Baba A","year":"1992","journal-title":"ASAIO J"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02948-w"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0021-9509.17.09864-0"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.02.005"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.14137","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.14137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:39:29Z","timestamp":1786156769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.14137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,14]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/aor.14137"],"URL":"https:\/\/doi.org\/10.1111\/aor.14137","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,14]]},"assertion":[{"value":"2021-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}