{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:45:07Z","timestamp":1786157107483,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>During extracorporeal life support (ECLS), bleeding is one of the most frequent complications, associated with high morbidity and increased mortality, despite continuous improvements in devices and patient care. Risk factors for bleeding complications in veno\u2010venous (V\u2010V) ECLS applied for respiratory support have been poorly investigated.<\/jats:p>\n                    <jats:p>We aim to develop and internally validate a prediction model to calculate the risk for bleeding complications in adult patients receiving V\u2010V ECLS support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from adult patients reported to the extracorporeal life support organization (ELSO) registry between the years 2010 and 2020 were analyzed. The primary outcome was bleeding complications recorded during V\u2010V ECLS. Multivariable logistic regression with backward stepwise elimination was used to develop the predictive model. The performance of the model was tested by discriminative ability and calibration with receiver operating characteristic curves and visual inspection of the calibration plot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 18 658 adult patients were included, of which 3 933 (21.1%) developed bleeding complications. The prediction model showed a prediction of bleeding complications with an AUC of 0.63. Pre\u2010ECLS arrest, surgical cannulation, lactate, pO\n                      <jats:sub>2<\/jats:sub>\n                      , HCO\n                      <jats:sub>3<\/jats:sub>\n                      , ventilation rate, mean airway pressure, pre\u2010ECLS cardiopulmonary bypass or renal replacement therapy, pre\u2010ECLS surgical interventions, and different types of diagnosis were included in the prediction model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The model is based on the largest cohort of V\u2010V ECLS patients and reveals the most favorable predictive value addressing bleeding events given the predictors that are feasible and when compared to the current literature. This model will help identify patients at risk of bleeding complications, and decision making in terms of anticoagulation and hemostatic management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.14148","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T01:45:20Z","timestamp":1639446320000},"page":"932-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["HEROES V\u2010V\u2014HEmorRhagic cOmplications in Veno\u2010Venous Extracorporeal life Support\u2014Development and internal validation of multivariable prediction model in adult patients"],"prefix":"10.1111","volume":"46","author":[{"given":"Anne","family":"Willers","sequence":"first","affiliation":[{"name":"ECLS Center, Cardio\u2010Thoracic Surgery Department, Heart &amp; Vascular Center Maastricht University Medical Center (MUMC)  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-092X","authenticated-orcid":false,"given":"Justyna","family":"Swol","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Paracelsus Medical University  Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-729X","authenticated-orcid":false,"given":"Sander M. 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